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645900 Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem

A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent.

Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PG490

Primary Target: Activate DEVD-cleaving caspases
645900
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Przegląd

Replacement Information

Tabela kluczowych gatunków

CAS #Empirical Formula
38748-32-2C₂₀H₂₄O₆

Products

Numer katalogowyOpakowanie Ilość/opak.
645900-1MG Ampulka plastikowa 1 mg
645900-5MG Ampulka plastikowa 5 mg
Description
OverviewA novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells by activating DEVD-cleaving caspases. Sensitizes tumor cells to TNF-α-induced apoptosis, and inhibits TNF-α-induced activation of NF-κB. Also inhibits T cell IL-2 expression at the level of purine-box/nuclear factor of activated T cells and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1).
Catalogue Number645900
Brand Family Calbiochem®
SynonymsPG490
References
ReferencesZhao, Q., et al. 2005. J. Biol. Chem. 280, 8101.
Shepherd, E., et al. 2004. J. Biol. Chem. 279, 54023.
Chan, M.A., et al. 1999. Phytother. Res. 13, 464.
Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451.
Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443.
Yang, Y., et al. 1998. Immunopharmacology 40, 139.
Product Information
CAS number38748-32-2
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₀H₂₄O₆
Chemical formulaC₂₀H₂₄O₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetActivate DEVD-cleaving caspases
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSYK7751000
Safety Information
R PhraseR: 20/21/22-40

Harmful by inhalation, in contact with skin and if swallowed.
Limited evidence of a carcinogenic effect.
S PhraseS: 22-36

Do not breathe dust.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
645900-1MG 04055977262193
645900-5MG 04055977262209

Documentation

Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem Certificates of Analysis

TitleLot Number
645900

References

Przegląd literatury
Zhao, Q., et al. 2005. J. Biol. Chem. 280, 8101.
Shepherd, E., et al. 2004. J. Biol. Chem. 279, 54023.
Chan, M.A., et al. 1999. Phytother. Res. 13, 464.
Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451.
Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443.
Yang, Y., et al. 1998. Immunopharmacology 40, 139.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-May-2009 RFH
SynonymsPG490
DescriptionA novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells, sensitizes tumor cells to TNF-α-induced activation of NF-κB. Also inhibits IL-2 expression in activated T-cells at the level of purine-box/nuclear factor and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1). Reported to induce apoptosis by activating DEVD-cleaving caspases.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number38748-32-2
RTECSYK7751000
Chemical formulaC₂₀H₂₄O₆
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (20 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
ReferencesZhao, Q., et al. 2005. J. Biol. Chem. 280, 8101.
Shepherd, E., et al. 2004. J. Biol. Chem. 279, 54023.
Chan, M.A., et al. 1999. Phytother. Res. 13, 464.
Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451.
Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443.
Yang, Y., et al. 1998. Immunopharmacology 40, 139.