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581011 Telomerase Inhibitor IX - CAS 368449-04-1 - Calbiochem

The Telomerase Inhibitor IX, also referenced under CAS 368449-04-1, controls the biological activity of Telomerase. This small molecule/inhibitor is primarily used for Cell Structure applications.

Telomerase Inhibitor IX - CAS 368449-04-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: MST-312, N,Nʹ-bis(2,3-Dihydroxybenzoyl)-1,3-phenylenediamine

Primary Target: TRAP lysate prepared from U937 cells
581011
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Przegląd

Replacement Information

Tabela kluczowych gatunków

CAS #Empirical Formula
368449-04-1C₂₀H₁₆N₂O₆

Products

Numer katalogowyOpakowanie Ilość/opak.
581011-10MG Ampulka plastikowa 10 mg
Description
OverviewA cell-permeable, bis-catechol containing, m-phenylenediamide compound that displays anti-proliferative properties. Acts as a potent, reversible inhibitor of telomerase activity (IC50 = 670 nM, TRAP lysate prepared from U937 cells). Prolonged treatment with MST-312 has been reported to result in telomere shortening and growth arrest in U937 cells. Does not inhibit the activity of Taq DNA polymerase (IC50 >3 µM).
Catalogue Number581011
Brand Family Calbiochem®
SynonymsMST-312, N,Nʹ-bis(2,3-Dihydroxybenzoyl)-1,3-phenylenediamine
References
ReferencesSeimiya, H., et al. 2005. Cancer Cell 7, 25.
Seimiya, H., et al. 2002. Mol. Cancer Ther. 1, 657.
Product Information
CAS number368449-04-1
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₀H₁₆N₂O₆
Chemical formulaC₂₀H₁₆N₂O₆
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetTRAP lysate prepared from U937 cells
Primary Target IC<sub>50</sub>670 nM against telomerase activity in TRAP lysate prepared from U937 cells
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
581011-10MG 04055977265613

Documentation

Telomerase Inhibitor IX - CAS 368449-04-1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Telomerase Inhibitor IX - CAS 368449-04-1 - Calbiochem Certificates of Analysis

TitleLot Number
581011

References

Przegląd literatury
Seimiya, H., et al. 2005. Cancer Cell 7, 25.
Seimiya, H., et al. 2002. Mol. Cancer Ther. 1, 657.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure