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616453 TGF-β RI Kinase Inhibitor III - CAS 356559-13-2 - Calbiochem

The TGF-β RI Kinase Inhibitor III, also referenced under CAS 356559-13-2, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation &

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TGF-β RI Kinase Inhibitor III - CAS 356559-13-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Transforming Growth Factor-β Type I Receptor Kinase Inhibitor III, 2-(5-Benzo[1,3]dioxol-4-yl-2-tert-butyl-1H-imidazol-4-yl)-6-methylpyridine, HCl, ALK5 Inhibitor III, SB-505124, HCl

Primary Target: Activin receptor-like kinase 4, 5, 7
616453
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Przegląd

Tabela kluczowych gatunków

CAS #Empirical Formula
356559-13-2C₂₀H₂₁N₃O₂ • HCl

Products

Numer katalogowyOpakowanie Ilość/opak.
616453-2MG Ampulka plastikowa 2 mg
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Description
OverviewA cell-permeable imidazolyl-pyridine compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of activin receptor-like kinase 4 (IC50 = 129 nM), 5 ( IC50 = 47 nM), and 7. It inhibits p38 MAPKα only at much higher concentrations (IC50 = 10.6 µM) and has little effect against ALK1/2/3/6 as well as a panel of 26 other kinases.
Catalogue Number616453
Brand Family Calbiochem®
SynonymsTransforming Growth Factor-β Type I Receptor Kinase Inhibitor III, 2-(5-Benzo[1,3]dioxol-4-yl-2-tert-butyl-1H-imidazol-4-yl)-6-methylpyridine, HCl, ALK5 Inhibitor III, SB-505124, HCl
References
ReferencesHu, T., et al. 2005. Am. J. Physiol. Renal Physiol. 289, F816.
DaCosta Byfield, S., et al. 2004. Mol. Pharmacol. 65, 744.
Product Information
CAS number356559-13-2
ATP CompetitiveY
FormLight yellow solid
Hill FormulaC₂₀H₂₁N₃O₂ • HCl
Chemical formulaC₂₀H₂₁N₃O₂ • HCl
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetActivin receptor-like kinase 4, 5, 7
Primary Target IC<sub>50</sub>129 nM, 47 nM, against activin receptor-like kinase 4, 5, respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Numer katalogowy GTIN
616453-2MG 04055977185843