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572635 SU6656 - CAS 330161-87-0 - Calbiochem

SU6656, CAS 330161-87-0, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of Src (IC50 = 280 nM). Also inhibits Fyn (IC50 = 170 nM), Yes (IC50 = 20 nM), and Lyn (IC50 = 130 nM).

SU6656 - CAS 330161-87-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Src
572635
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Przegląd

Replacement Information

Tabela kluczowych gatunków

CAS #Empirical Formula
330161-87-0C₁₉H₂₁N₃O₃S

Products

Numer katalogowyOpakowanie Ilość/opak.
572635-1MG Ampulka plastikowa 1 mg
Description
OverviewA potent, cell-permeable, reversible, and ATP-competitive Src family kinase inhibitor. Inhibits Src (IC50 = 280 nM) as well as closely related kinases such as Fyn (IC50 = 170 nM) and Yes (IC50 = 20 nM) and Lyn (IC50 = 130 nM). Acts as a weak inhibitor of Lck (IC50 = 688 µM) and PDGF receptor kinase (IC50 >10 µM). A 10 mM (500 µg/135 µl) solution of SU6656 (Cat. No. 572636) in DMSO is also available.
Catalogue Number572635
Brand Family Calbiochem®
References
ReferencesBowman, T., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 7319.
Blake, R.A., et al. 2000. Mol. Cell. Biol. 20, 9018.
Product Information
CAS number330161-87-0
ATP CompetitiveY
FormBurnt orange solid
Hill FormulaC₁₉H₂₁N₃O₃S
Chemical formulaC₁₉H₂₁N₃O₃S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationSU6656, CAS 330161-87-0, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of Src (IC50 = 280 nM). Also inhibits Fyn (IC50 = 170 nM), Yes (IC50 = 20 nM), and Lyn (IC50 = 130 nM).
Biological Information
Primary TargetSrc
Primary Target IC<sub>50</sub>280 nM, 170 nM, 20 nM, and 130 nM against Src, Fyn, Yes, and Lyn.
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
572635-1MG 04055977266290

Documentation

SU6656 - CAS 330161-87-0 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

SU6656 - CAS 330161-87-0 - Calbiochem Certificates of Analysis

TitleLot Number
572635

References

Przegląd literatury
Bowman, T., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 7319.
Blake, R.A., et al. 2000. Mol. Cell. Biol. 20, 9018.

Citations

Tytuł
  • Malcolm A. Meyn, et al. (2005) Src family kinase activity is required for murine embryonic stem cell growth and differentiation. Molecular Pharmacology 68, 1320-1330.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision17-March-2010 JSW
    DescriptionA potent, cell-permeable, reversible, and ATP-competitive inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC50 = 280 nM) as well as closely related kinases Fyn (IC50 = 170 nM), Yes (IC50 = 20 nM) and Lyn (IC50 = 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC50 = 6.88 µM). Does not affect the activity of PDGF-β receptor kinase (IC50 ≥10 µM) and IGF-1 receptor kinase (IC50 ≥20 µM).
    FormBurnt orange solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number330161-87-0
    Chemical formulaC₁₉H₂₁N₃O₃S
    Structure formulaStructure formula
    Purity≥97% by HPLC
    SolubilityDMSO (25 mg/ml)
    Storage Protect from light
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Standard Handling
    ReferencesBowman, T., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 7319.
    Blake, R.A., et al. 2000. Mol. Cell. Biol. 20, 9018.
    Citation
  • Malcolm A. Meyn, et al. (2005) Src family kinase activity is required for murine embryonic stem cell growth and differentiation. Molecular Pharmacology 68, 1320-1330.
    		•