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573096 STAT3 Inhibitor Peptide, Cell-Permeable

STAT3 Inhibitor Peptide, Cell-Permeable, is an analog of Stat3-SH2 domain-binding phosphopeptide with a C-terminal membrane translocating sequence. A selective, potent blocker of Stat3 activation.

STAT3 Inhibitor Peptide, Cell-Permeable MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PpYLKTK-mts, STAT3 Inhibitor IV

Primary Target: Blocker of Stat3 activation
573096
Purchase on Sigma-Aldrich

Przegląd

Replacement Information

Tabela kluczowych gatunków

Empirical Formula
C₉₂H₁₅₇N₂₀O₂₄P

Products

Numer katalogowyOpakowanie Ilość/opak.
573096-1MG Ampulka plastikowa 1 mg
573096-5MG Ampulka plastikowa 5 mg
Description
OverviewA cell-permeable analog of the Stat3-SH2 domain-binding phosphopeptide (Cat. No. 573095) that contains a C-terminal mts (membrane translocating sequence) and acts as a highly selective, potent blocker of Stat3 activation. Also suppresses constitutive Stat-3 dependent Src transformation with no effect on Stat-3 independent Ras transformation. The unphosphorylated inactive control peptide is also available under Cat. No. 573105.
Supplied as a trifluoroacetate salt.
Catalogue Number573096
Brand Family Calbiochem®
SynonymsPpYLKTK-mts, STAT3 Inhibitor IV
References
ReferencesTurkson, J., et al. 2001. J. Biol. Chem. 276, 45443.
Rojas, M., et al. 1998. Nat. Biotechnol. 16, 370.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₉₂H₁₅₇N₂₀O₂₄P
Chemical formulaC₉₂H₁₅₇N₂₀O₂₄P
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
ApplicationSTAT3 Inhibitor Peptide, Cell-Permeable, is an analog of Stat3-SH2 domain-binding phosphopeptide with a C-terminal membrane translocating sequence. A selective, potent blocker of Stat3 activation.
Biological Information
Primary TargetBlocker of Stat3 activation
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceH-Pro-Tyr-(PO₃H₂)-Leu-Lys-Thr-Lys-Ala-Ala-Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
573096-1MG 07790788051730
573096-5MG 07790788051747

Documentation

STAT3 Inhibitor Peptide, Cell-Permeable MSDS

Title

Safety Data Sheet (SDS) 

STAT3 Inhibitor Peptide, Cell-Permeable Certificates of Analysis

TitleLot Number
573096

References

Przegląd literatury
Turkson, J., et al. 2001. J. Biol. Chem. 276, 45443.
Rojas, M., et al. 1998. Nat. Biotechnol. 16, 370.

Brochure

Title
An Introduction to Inhibitors and Their Biological Applications - 1st Edition

Technical Info

Title
JAK/STAT Signaling Research Focus

Citations

Tytuł
  • Rob D. Catalano, et al. (2005) Inhibition of STAT3 activation in the endometrium prevents implantation: a nonsteroidal approach to contraception. Proceedings of the National Academy of Science USA in press,.
  • Yoshinari Tanabe, et al. (2005) Role of STAT1, STAT3, and STAT5 in IFN-αβ responses in T lymphocytes. Journal of Immunology 174, 609-613.
  • Egle Avizienyte, et al. (2004) Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition. Molecular Biology of the Cell 15, 2794-2803.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision12-September-2008 RFH
    SynonymsPpYLKTK-mts, STAT3 Inhibitor IV
    DescriptionA cell-permeable analog of the Stat3-SH2 domain-binding phospho-peptide (Cat. No. 573095) that contains a C-terminal membrane translocating sequence (MTS) and acts as a highly selective, potent blocker of Stat3 activation. Also suppresses constitutive Stat3-dependent Src transformation with no effect on Stat3-independent Ras transformation.
    FormWhite lyophilized solid
    FormulationSupplied as a trifluoroacetate salt.
    Intert gas (Yes/No) Packaged under inert gas
    Chemical formulaC₉₂H₁₅₇N₂₀O₂₄P
    Peptide SequenceH-Pro-Tyr-(PO₃H₂)-Leu-Lys-Thr-Lys-Ala-Ala-Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro-OH
    Purity≥95% by HPLC
    SolubilityH₂O (1 mg/ml)
    Storage -20°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
    Toxicity Standard Handling
    ReferencesTurkson, J., et al. 2001. J. Biol. Chem. 276, 45443.
    Rojas, M., et al. 1998. Nat. Biotechnol. 16, 370.
    Citation
  • Rob D. Catalano, et al. (2005) Inhibition of STAT3 activation in the endometrium prevents implantation: a nonsteroidal approach to contraception. Proceedings of the National Academy of Science USA in press,.
  • Yoshinari Tanabe, et al. (2005) Role of STAT1, STAT3, and STAT5 in IFN-αβ responses in T lymphocytes. Journal of Immunology 174, 609-613.
  • Egle Avizienyte, et al. (2004) Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition. Molecular Biology of the Cell 15, 2794-2803.
    		•