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14-652M SIK Protein, active, 250 µg

Active, N-terminal 6His-tagged, recombinant, human SIK, amino acids 1-281. For use in Kinase Assays.

SIK Protein, active, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
14-652M
250 µg  Also available in 10 μg size (cat#14-652) and in bulk (cat# 14-652-K).
Purchase on Sigma-Aldrich

Przegląd

Replacement Information
Description
Catalogue Number14-652M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionSIK Protein, active, 250 µg
OverviewN-terminal 6His-tagged, recombinant, human SIK, amino acids 1-281.
References
Product Information
Quality LevelMQ300
Applications
ApplicationActive, N-terminal 6His-tagged, recombinant, human SIK, amino acids 1-281. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceExpressed by baculovirus in Sf21 insect cells.
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Gene Symbol
  • SNF1LK
  • MSK
  • msk
  • SIK
  • SIK1
Protein TargetSIK
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyCAMK
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P57059 # Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3 (By similarity).
COFACTOR: Magnesium.
SIZE: 783 amino acids; 84902 Da
SUBUNIT: Binds to and is activated by YWHAZ when phosphorylated on Thr-182.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: SwissProt: P57059 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily. & Contains 1 protein kinase domain. & Contains 1 UBA domain.
Molecular Weight36.2kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of AMARA Substrate Peptide (Catalog# 12-557).
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 6 months at -70°C from date of shipment
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-652) and in bulk (cat# 14-652-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
14-652M 04053252411816

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Alternative Packsize

Numer katalogowy Opis
14-652 SIK Protein, active, 10 µg

Product Families

Kinase & Phosphatase Products

Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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Kategorie

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases