Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

559396 SB 220025

A cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC₅₀ = 60 nM).

SB 220025 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole, p38 MAP Kinase Inhibitor XIV

Primary Target: P38MAPK
559396
Purchase on Sigma-Aldrich

Przegląd

Replacement Information

Tabela kluczowych gatunków

CAS #Empirical Formula
165806-53-1C₁₈H₁₉FN₆

Products

Numer katalogowyOpakowanie Ilość/opak.
559396-500UG Ampulka plastikowa 500 μg
Description
OverviewA cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC50 = 60 nM). Binds to an extended pocket in the active site of the enzyme. Exhibits over 2000-fold greater selectivity for p38 MAPK over ERK (p42/p44 MAP kinase), 500-fold over PKA, 50-fold over PKC, and >1000-fold over EGFR. Also acts as a potent inhibitor of angiogenesis and as an inhibitor of LPS-induced TNF-α production.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number559396
Brand Family Calbiochem®
Synonyms5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole, p38 MAP Kinase Inhibitor XIV
References
ReferencesJackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther. 284, 687.
Wang, Z., et al. 1998. Structure 6, 1117.
Product Information
CAS number165806-53-1
FormWhite to pale yellow solid
Hill FormulaC₁₈H₁₉FN₆
Chemical formulaC₁₈H₁₉FN₆
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetP38MAPK
Primary Target IC<sub>50</sub>60 nM
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
559396-500UG 07790788051549

Documentation

SB 220025 MSDS

Title

Safety Data Sheet (SDS) 

SB 220025 Certificates of Analysis

TitleLot Number
559396

References

Przegląd literatury
Jackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther. 284, 687.
Wang, Z., et al. 1998. Structure 6, 1117.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision21-November-2014 JSW
Synonyms5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole, p38 MAP Kinase Inhibitor XIV
DescriptionA potent and specific inhibitor of human p38 mitogen-activated protein (MAP) kinase (IC50 = 60 nM). Binds to an extended pocket in the active site of the enzyme. Exhibits >2500-fold greater selectivity for p38 MAPK over ERK (p42/p44 MAP kinase), 500-fold over PKA, 50-fold over PKC, and >1600-fold over EGFRK. Also acts as a potent inhibitor of angiogenesis and as an inhibitor of LPS-induced TNF-α production.
FormWhite to pale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number165806-53-1
Chemical formulaC₁₈H₁₉FN₆
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (22 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesJackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther. 284, 687.
Wang, Z., et al. 1998. Structure 6, 1117.