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557440 Ru360 - Calbiochem

Ru360, is a cell-permeable oxygen-bridged dinuclear ruthenium amine complex. Binds to mitochondria with high affinity (Kd = 340 pM) and blocks Ca2+ uptake into mitochondria in vitro (IC₅₀ = 184 pM).

Ru360 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (μ)[(HCO₂)(NH₃)₄Ru]₂OCl₃

Primary Target: Ca2+ uptake into mitochondria in vitro
557440
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Przegląd

Tabela kluczowych gatunków

Empirical Formula
C₂H₂₆Cl₃N₈O₅Ru₂

Products

Numer katalogowyOpakowanie Ilość/opak.
557440-1SET Butelka szklana 1 set
Dodaj do Ulubionych
557440-500UG Ampulka plastikowa 500 μg
Dodaj do Ulubionych
Description
OverviewA cell-permeable oxygen-bridged dinuclear ruthenium amine complex that has been shown to bind to mitochondria with high affinity (Kd = 340 pM). Specifically blocks Ca2+ uptake into mitochondria in vitro (IC50 = 184 pM) and in situ in intact myocytes (complete block after incubation with ~10 µM of Ru360 for 30 min). Does not affect other cellular Ca2+ transport processes involved in cardiac muscle contraction, even at micromolar levels.
Note: 1 set = 10 x 100 µg.
Catalogue Number557440
Brand Family Calbiochem®
Synonyms(μ)[(HCO₂)(NH₃)₄Ru]₂OCl₃
References
ReferencesSanchez, J.A., et al. 2001. J. Physiol. 536, 387.
Bassani, R.A., et al. 1998. Cell Calcium 23, 433.
Matlib, M.A., et al. 1998. J. Biol. Chem. 273, 10223.
Zhou, Z., et al. 1998. J. Physiol. 507 (pt 2), 379.
Emerson, J., et al. 1993. J. Am. Chem. Soc. 115, 11799.
Ying, W.-L., et al. 1991. Biochemistry 30, 4949.
Product Information
ATP CompetitiveN
FormGreen solid
Hill FormulaC₂H₂₆Cl₃N₈O₅Ru₂
Chemical formulaC₂H₂₆Cl₃N₈O₅Ru₂
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetCa2+ uptake into mitochondria in vitro
Primary Target IC<sub>50</sub>184 pM blocking Ca2+ uptake into mitochondria in vitro; and in situ in intact myocytes; Kd = 340 pM for binding mitochondria
Purity≥97%
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Numer katalogowy GTIN
557440-1SET 07790788051501
557440-500UG 04055977268089