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557368 Rotenone - CAS 83-79-4 - Calbiochem

A mitochondrial toxin and a potent, reversible, and competitive inhibitor of complex I (NADH-CoQ reductase) of the respiratory chain.

Rotenone - CAS 83-79-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: NADH-CoQ reductase
557368
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Przegląd

Replacement Information

Tabela kluczowych gatunków

CAS #Empirical Formula
83-79-4C₂₃H₂₂O₆

Products

Numer katalogowyOpakowanie Ilość/opak.
557368-1GM Butelka szklana 1 gm
Description
OverviewA mitochondrial toxin and a potent, reversible, and competitive inhibitor of complex I (NADH-CoQ reductase) of the respiratory chain. Also inhibits cellular proliferation in mouse liver.
Catalogue Number557368
Brand Family Calbiochem®
References
ReferencesKopustinskiene, D.M., et al. 2001. Eur. J. Pharmacol. 428, 311.
Higgins, D.S., Jr. and Greenamyre, J.T. 1996. J. Neurosci. 16, 3807.
Cunningham, M.L., et al. 1995. Cancer Lett. 95, 93.
Product Information
CAS number83-79-4
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₂₃H₂₂O₆
Chemical formulaC₂₃H₂₂O₆
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNADH-CoQ reductase
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSDJ2800000
Safety Information
R PhraseR: 25-36/37/38-50/53

Toxic if swallowed.
Irritating to eyes, respiratory system and skin.
Very toxic to aquatic organisms; may cause long-term adverse effects in the aquatic environment.
S PhraseS: 22-24/25-36-45-60-61

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
This material and its container must be disposed of as hazardous waste.
Avoid release to the environment. Refer to special instructions/safety data sheet.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, flush with nitrogen, and store at -70°C. Stock solutions are stable for up to 1 month at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
557368-1GM 04055977268034

Documentation

Rotenone - CAS 83-79-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Rotenone - CAS 83-79-4 - Calbiochem Certificates of Analysis

TitleLot Number
557368

References

Przegląd literatury
Kopustinskiene, D.M., et al. 2001. Eur. J. Pharmacol. 428, 311.
Higgins, D.S., Jr. and Greenamyre, J.T. 1996. J. Neurosci. 16, 3807.
Cunningham, M.L., et al. 1995. Cancer Lett. 95, 93.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-October-2019 JSW
DescriptionA mitochondrial toxin and a potent, reversible and competitive inhibitor of complex I (NADH-CoQ reductase) of the respiratory chain. Also inhibits cellular proliferation in mouse liver.
FormWhite to off-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number83-79-4
RTECSDJ2800000
Chemical formulaC₂₃H₂₂O₆
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityChloroform (50 mg/ml), DMSO (50 mg/ml), or ethanol (5 mg/ml)
Storage Protect from light
+15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, flush with nitrogen, and store at -70°C. Stock solutions are stable for up to 1 month at -70°C.
Toxicity Toxic
Merck USA index14 8271
ReferencesKopustinskiene, D.M., et al. 2001. Eur. J. Pharmacol. 428, 311.
Higgins, D.S., Jr. and Greenamyre, J.T. 1996. J. Neurosci. 16, 3807.
Cunningham, M.L., et al. 1995. Cancer Lett. 95, 93.