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554325 Resveratrol - CAS 501-36-0 - Calbiochem

A phenolic product found in both grape skins and wines.

Resveratrol - CAS 501-36-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: trans-3,4ʹ,5-Trihydroxystilbene

Primary Target: COX-1
554325
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Przegląd

Replacement Information

Tabela kluczowych gatunków

CAS #Empirical Formula
501-36-0C₁₄H₁₂O₃

Products

Numer katalogowyOpakowanie Ilość/opak.
554325-25MG Ampulka plastikowa 25 mg
Description
OverviewA phenolic product found in both grape skins and wines. Has antifungal, antitumor, and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED50 = 15 µM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED50 = 3.7 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED50 = 27 µM) and acts as an anti-mutagenic agent (ED50 = 15 µM) in TM677 cells treated with DMBA. Also a selective inhibitor of P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells.
Catalogue Number554325
Brand Family Calbiochem®
Synonymstrans-3,4ʹ,5-Trihydroxystilbene
References
ReferencesHowitz, K.T., et al. 2003. Nature 425, 191.
Lin, H.Y., et al. 2002. J. Urol. 168, 748.
Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun. 262, 20.
Jang, M., et al. 1997. Science 275, 218.
Chen, C.K., et al. 1996. Gen. Pharmacol. 27, 363.
Product Information
CAS number501-36-0
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₁₄H₁₂O₃
Chemical formulaC₁₄H₁₂O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCOX-1
Primary Target IC<sub>50</sub>ED50 = 15 µM against COX-1
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
554325-25MG 04055977193053

Documentation

Resveratrol - CAS 501-36-0 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Resveratrol - CAS 501-36-0 - Calbiochem Certificates of Analysis

TitleLot Number
554325

References

Przegląd literatury
Howitz, K.T., et al. 2003. Nature 425, 191.
Lin, H.Y., et al. 2002. J. Urol. 168, 748.
Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun. 262, 20.
Jang, M., et al. 1997. Science 275, 218.
Chen, C.K., et al. 1996. Gen. Pharmacol. 27, 363.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-December-2018 JSW
Synonymstrans-3,4ʹ,5-Trihydroxystilbene
DescriptionA phenolic product found in both grape skin and wines. Has anti-fungal, anti-tumor and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED50 = 15 µM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED50 = 3.7 µM). Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED50 = 27 µM) and acts as an anti-mutagenic agent (ED50 = 15 µM) in TM677 cells treated with DMBA. Also selectively inhibits P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells.
FormOff-white solid
CAS number501-36-0
Chemical formulaC₁₄H₁₂O₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
Merck USA index14, 8158
ReferencesHowitz, K.T., et al. 2003. Nature 425, 191.
Lin, H.Y., et al. 2002. J. Urol. 168, 748.
Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun. 262, 20.
Jang, M., et al. 1997. Science 275, 218.
Chen, C.K., et al. 1996. Gen. Pharmacol. 27, 363.