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523310 Pterostilbene, Pterocarpus marsupium - CAS 537-42-8 - Calbiochem

A cell-permeable methoxylated analog of Resveratrol that displays antioxidant, antiproliferative, and hypoglycemic properties.

Pterostilbene, Pterocarpus marsupium - CAS 537-42-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: trans-3,5-Dimethoxy-4ʹ-hydroxystilbene

Primary Target: COX-1 and COX-2 activities
523310
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Przegląd

Replacement Information

Tabela kluczowych gatunków

CAS #Empirical Formula
537-42-8C₁₆H₁₆O₃

Products

Numer katalogowyOpakowanie Ilość/opak.
523310-10MG Butelka szklana 10 mg
Description
OverviewA cell-permeable methoxylated analog of Resveratrol (Cat. No. 554325) that displays antioxidant, antiproliferative, and hypoglycemic properties. Moderately inhibits COX-1 and -2 activities (IC50 = 19.8 µM and 83.9 µM) respectively, induces apoptosis in HL60 cells (IC50 = 70 µM), prevents DMBA-induced preneoplastic lesions (ED50 = 4.8 µM) and decreases plasma glucose level in streptozotocin-induced diabetic rats comparable to that of Metformin.
Catalogue Number523310
Brand Family Calbiochem®
Synonymstrans-3,5-Dimethoxy-4ʹ-hydroxystilbene
References
ReferencesRoberti, M., et al. 2003. J. Med. Chem. 46, 3546.
Rimando, A.M., et al. 2002. J. Agric. Food Chem. 50, 3453.
Manickam, M., et al. 1997. J. Nat. Prod. 60, 609.
Product Information
CAS number537-42-8
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₁₆H₁₆O₃
Chemical formulaC₁₆H₁₆O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCOX-1 and COX-2 activities
Primary Target IC<sub>50</sub>19.8 µM, 83.9 µM against COX-1 and -2 activities, respectively; 70 µM for inducing apoptosis in HL60 cells; ED50 = 4.8 µM for preventing DMBA-induced preneoplastic lesions
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C.). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
523310-10MG 04055977271485

Documentation

Pterostilbene, Pterocarpus marsupium - CAS 537-42-8 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Pterostilbene, Pterocarpus marsupium - CAS 537-42-8 - Calbiochem Certificates of Analysis

TitleLot Number
523310

References

Przegląd literatury
Roberti, M., et al. 2003. J. Med. Chem. 46, 3546.
Rimando, A.M., et al. 2002. J. Agric. Food Chem. 50, 3453.
Manickam, M., et al. 1997. J. Nat. Prod. 60, 609.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-October-2007 JSW
Synonymstrans-3,5-Dimethoxy-4ʹ-hydroxystilbene
DescriptionA cell-permeable methoxylated analog of Resveratrol (Cat. No. 554325) that displays antioxidant, anti-proliferative, and hypoglycemic properties. Appears to be a better free radical scavenger than Trolox® (Cat. No. 64847). Moderately inhibits COX-1 & COX-2 activities (IC50 = 19.8 µM & 83.9 µM, respectively) and induces apoptosis in HL60 cells (IC50 = 70 µM). Also prevents DMBA-induced pre-neoplastic lesions (ED50 = 4.8 µM). Reported to decrease plasma glucose levels in streptozotocin-induced diabetic rats comparable to that of Metformin.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number537-42-8
Chemical formulaC₁₆H₁₆O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml) or Methanol (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C.). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesRoberti, M., et al. 2003. J. Med. Chem. 46, 3546.
Rimando, A.M., et al. 2002. J. Agric. Food Chem. 50, 3453.
Manickam, M., et al. 1997. J. Nat. Prod. 60, 609.