539160 Sigma-AldrichProteasome Inhibitor I - Calbiochem
The Proteasome Inhibitor I controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
More>> The Proteasome Inhibitor I controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Less<<Proteasome Inhibitor I - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: PSI
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Przegląd
| Replacement Information |
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Tabela kluczowych gatunków
| Empirical Formula |
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| C₃₂H₅₀N₄O₈ |
Products
| Numer katalogowy | Opakowanie | Ilość/opak. | |
|---|---|---|---|
| 539160-1MG | Ampulka plastikowa | 1 mg | |
| 539160-5MG | Ampulka plastikowa | 5 mg |
| Description | |
|---|---|
| Overview | A cell-permeable, reversible inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells. Causes the accumulation of ubiquitinated proteins in neuronal cells. Prevents the activation of NF-κB in response to TNF-α and Okadaic Acid (Cat. No. 495604) through inhibition of IκB-α degradation. A 50 mM (5 mg/162 µl) solution of Proteasome Inhibitor I (Cat. No. 539161) in DMSO is also available. |
| Catalogue Number | 539160 |
| Brand Family | Calbiochem® |
| Synonyms | PSI |
| Product Information | |
|---|---|
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₃₂H₅₀N₄O₈ |
| Chemical formula | C₃₂H₅₀N₄O₈ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells |
| Purity | ≥90% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Peptide Sequence | Z-Ile-Glu(OtBu)-Ala-Leu-CHO |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information |
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| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Numer katalogowy | GTIN |
| 539160-1MG | 04055977269420 |
| 539160-5MG | 04055977269437 |
Documentation
Proteasome Inhibitor I - Calbiochem MSDS
| Title |
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Proteasome Inhibitor I - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 539160 |
References
| Przegląd literatury |
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| Griscavage, J.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3308. Mori, S., et al. 1995. J. Biol. Chem. 270, 29447. Figueiredo-Pereira, M.E., et al. 1994. J. Neurochem. 63, 1578. Traenckner, E.B., et al. 1994. EMBO J. 13, 5433. |
Brochure
| Title |
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| Caspases and other Apoptosis Related Tools Brochure |
| Proteasomes Technical Bulletin |
Citations
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| Data Sheet | ||||||||||||||||||||||||||||||
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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