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4995 Ouabain, Octahydrate - CAS 11018-89-6 - Calbiochem

Ouabain, Octahydrate, CAS 11018-89-6, is an inhibitor of Na+,K+-ATPase. Exhibits cardiotonic properties and enhances radiotoxicity in tumor cells to induce apoptosis.

Ouabain, Octahydrate - CAS 11018-89-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Strophanthin G

Primary Target: Na+,K+-ATPase
4995
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Przegląd

Replacement Information

Tabela kluczowych gatunków

CAS #Empirical Formula
11018-89-6C₂₉H₄₄O₁₂ · 8H₂O

Products

Numer katalogowyOpakowanie Ilość/opak.
4995-1GM Butelka szklana 1 gm
Description
OverviewInhibits Na+,K+-ATPase. Exhibits cardiotonic properties. Preferentially enhances radiotoxicity in tumor cells and induces apoptosis by prolonging the irradiation-induced G2 delay.
Catalogue Number4995
Brand Family Calbiochem®
SynonymsStrophanthin G
References
ReferencesVerheye-Dua, F.A., and Bohm, L. 2000. Strahlenther Onkol. 176, 186.
Hasenauer, J., et al. 1993. J. Biol. Chem. 268, 3289.
Rakowski, F.F. 1993. J. Gen. Physiol. 101, 117.
Mahaney, J.E., and Grisham, C.M. 1992. Biochemistry 31, 2025.
Xu, Z.J., et al. 1992. J. Physiol. 456, 405.
Product Information
CAS number11018-89-6
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₂₉H₄₄O₁₂ · 8H₂O
Chemical formulaC₂₉H₄₄O₁₂ · 8H₂O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationOuabain, Octahydrate, CAS 11018-89-6, is an inhibitor of Na+,K+-ATPase. Exhibits cardiotonic properties and enhances radiotoxicity in tumor cells to induce apoptosis.
Biological Information
Primary TargetNa+,K+-ATPase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSRN3850000
Safety Information
R PhraseR: 26/27/28

Very toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 2 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
4995-1GM 04055977199253

Documentation

Ouabain, Octahydrate - CAS 11018-89-6 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Ouabain, Octahydrate - CAS 11018-89-6 - Calbiochem Certificates of Analysis

TitleLot Number
4995

References

Przegląd literatury
Verheye-Dua, F.A., and Bohm, L. 2000. Strahlenther Onkol. 176, 186.
Hasenauer, J., et al. 1993. J. Biol. Chem. 268, 3289.
Rakowski, F.F. 1993. J. Gen. Physiol. 101, 117.
Mahaney, J.E., and Grisham, C.M. 1992. Biochemistry 31, 2025.
Xu, Z.J., et al. 1992. J. Physiol. 456, 405.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-January-2014 JSW
SynonymsStrophanthin G
DescriptionInhibits Na+ and K+-dependent ATPases. Has cardiotonic properties.
FormWhite to off-white solid
CAS number11018-89-6
RTECSRN3850000
Chemical formulaC₂₉H₄₄O₁₂ · 8H₂O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityHot H₂O (10 mg/ml). Not soluble in room temperature water.
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 2 months at -20°C.
Toxicity Toxic
Merck USA index14 6901
ReferencesVerheye-Dua, F.A., and Bohm, L. 2000. Strahlenther Onkol. 176, 186.
Hasenauer, J., et al. 1993. J. Biol. Chem. 268, 3289.
Rakowski, F.F. 1993. J. Gen. Physiol. 101, 117.
Mahaney, J.E., and Grisham, C.M. 1992. Biochemistry 31, 2025.
Xu, Z.J., et al. 1992. J. Physiol. 456, 405.