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481411 NF-κB Activation Inhibitor III - CAS 380623-76-7 - Calbiochem

The NF-κB Activation Inhibitor III, also referenced under CAS 380623-76-7, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

NF-κB Activation Inhibitor III - CAS 380623-76-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide, SM-7368

Primary Target: TNF-α-stimulated NF-κB activation and upregulation of MMP-9
481411
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Przegląd

Replacement Information

Tabela kluczowych gatunków

CAS #Empirical Formula
380623-76-7C₁₀H₅ClN₄O₅S

Products

Numer katalogowyOpakowanie Ilość/opak.
481411-5MG Butelka szklana 5 mg
Description
OverviewA cell-permeable thiazoloamide compound that inhibits TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µM). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-α-dependent cell invasion. Does not affect TNF-α-induced AP-1 activity. The cellular target appears to be downstream of p38 activation.
Catalogue Number481411
Brand Family Calbiochem®
Synonyms3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide, SM-7368
References
ReferencesLee, H.Y., et al. 2005. Biochem. Biophys. Res. Commun. 336, 716.
Product Information
CAS number380623-76-7
ATP CompetitiveN
FormLight yellow amorphous solid
Hill FormulaC₁₀H₅ClN₄O₅S
Chemical formulaC₁₀H₅ClN₄O₅S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetTNF-α-stimulated NF-κB activation and upregulation of MMP-9
Primary Target IC<sub>50</sub>Effective concentration: 10 µM for complete inhibition of TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
481411-5MG 04055977183719

Documentation

NF-κB Activation Inhibitor III - CAS 380623-76-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

NF-κB Activation Inhibitor III - CAS 380623-76-7 - Calbiochem Certificates of Analysis

TitleLot Number
481411

References

Przegląd literatury
Lee, H.Y., et al. 2005. Biochem. Biophys. Res. Commun. 336, 716.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-August-2008 RFH
Synonyms3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide, SM-7368
DescriptionA cell-permeable inhibitor of TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µM). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-α-dependent cell invasion. Does not affect TNF-α-induced AP-1 activity. The cellular target appears to be downstream of p38 activation.
FormLight yellow amorphous solid
Intert gas (Yes/No) Packaged under inert gas
CAS number380623-76-7
Chemical formulaC₁₀H₅ClN₄O₅S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesLee, H.Y., et al. 2005. Biochem. Biophys. Res. Commun. 336, 716.