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475880 ML-7, Hydrochloride - CAS 110448-33-4 - Calbiochem

ML-7, Hydrochloride, CAS 110448-33-4, is a cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM).

ML-7, Hydrochloride - CAS 110448-33-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(5-Iodonaphthalene-1-sulfonyl)homopiperazine, HCl

Primary Target: Myosin light chain kinase (Mlck)
475880
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Przegląd

Replacement Information

Tabela kluczowych gatunków

CAS #Empirical Formula
110448-33-4C₁₅H₁₇IN₂O₂S · HCl

Products

Numer katalogowyOpakowanie Ilość/opak.
475880-1MG Ampulka plastikowa 1 mg
Description
OverviewA cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). Inhibits protein kinase A (Ki = 21 µM) and protein kinase C (Ki = 42 µM) at much higher concentrations.
Catalogue Number475880
Brand Family Calbiochem®
Synonyms1-(5-Iodonaphthalene-1-sulfonyl)homopiperazine, HCl
References
ReferencesKrarup, T., et al. 1998. Am. J. Physiol. 275, C239.
Saitoh, M., et al. 1987. J. Biol. Chem. 262, 7796.
Product Information
CAS number110448-33-4
ATP CompetitiveY
FormWhite solid
Hill FormulaC₁₅H₁₇IN₂O₂S · HCl
Chemical formulaC₁₅H₁₇IN₂O₂S · HCl
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationML-7, Hydrochloride, CAS 110448-33-4, is a cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM).
Biological Information
Primary TargetMyosin light chain kinase (Mlck)
Primary Target K<sub>i</sub>300 nM against myosin light chain kinase
Purity>98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
475880-1MG 04055977203493

Documentation

ML-7, Hydrochloride - CAS 110448-33-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

ML-7, Hydrochloride - CAS 110448-33-4 - Calbiochem Certificates of Analysis

TitleLot Number
475880

References

Przegląd literatury
Krarup, T., et al. 1998. Am. J. Physiol. 275, C239.
Saitoh, M., et al. 1987. J. Biol. Chem. 262, 7796.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-January-2010 RFH
Synonyms1-(5-Iodonaphthalene-1-sulfonyl)homopiperazine, HCl
DescriptionA cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). Inhibits protein kinase A (Ki = 21 µM) and protein kinase C (Ki = 42 µM) at much higher concentrations.
FormWhite solid
CAS number110448-33-4
Chemical formulaC₁₅H₁₇IN₂O₂S · HCl
Structure formulaStructure formula
Purity>98% by TLC
SolubilityDMSO (4.5 mg/ml) or 50% ethanol (4.5 mg/ml). Further dilute with aqueous buffer just prior to use.
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Toxicity Standard Handling
ReferencesKrarup, T., et al. 1998. Am. J. Physiol. 275, C239.
Saitoh, M., et al. 1987. J. Biol. Chem. 262, 7796.