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14-543M MKK7β1 Protein, active, 250 µg

Active, N-terminal GST-tagged, recombinant, human MKK7β1, amino acids 2-end. For use in Kinase Assays.

MKK7β1 Protein, active, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
14-543M
250 µg  Also available in 10 μg size (cat#14-543) and in bulk (cat# 14-543-K).
Purchase on Sigma-Aldrich

Przegląd

Replacement Information
Description
Catalogue Number14-543M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionMKK7β1 Protein, active, 250 µg
OverviewN-terminal GST-tagged, recombinant, human MKK7β1, amino acids 2-end.
References
Product Information
Quality LevelMQ300
Applications
ApplicationActive, N-terminal GST-tagged, recombinant, human MKK7β1, amino acids 2-end. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceHuman MKK7β expressed in E. coli.
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.
Gene Symbol
  • MAP2K7
  • MKK7
  • PRKMK7
  • MEK7
  • MAPKK7
  • JNKK2
  • Jnkk2
Protein TargetMKK7β1
Purification Methodglutathione-agarose, activated with MEKK
Target Sub-FamilySTE
UniProt Number
UniProt SummaryFUNCTION: SwissProt: O14733 # Stress activated, dual specificity kinase that activates the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.
COFACTOR: Magnesium.
SIZE: 419 amino acids; 47485 Da
SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity).
TISSUE SPECIFICITY: Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.
PTM: Activated by phosphorylation on Ser/Thr.
SIMILARITY: SwissProt: O14733 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.
Molecular Weight74kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of JNK1α1/SAPK1c
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-543) and in bulk (cat# 14-543-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
14-543M 04053252583087

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Numer katalogowy Opis
14-543 MKK7β1 Protein, active, 10 µg

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Kategorie

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases