Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

19-164 HA1077

HA1077 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Uni Prot Number: O75116, Q16513, O75582, P51812, P17612, P23443, Q15746
19-164
5 mg  
Purchase on Sigma-Aldrich

Przegląd

Replacement Information

Tabela kluczowych gatunków

Uni Prot Number
O75116 Q16513 O75582 P51812 P17612 P23443 Q15746
Description
Catalogue Number19-164
Brand Family Upstate
Trade Name
  • Upstate
DescriptionHA1077
References
Product Information
PresentationC14H17N3O2S2HCl
Quality LevelMQ100
Applications
Key Applications
  • Kinase Assay
Application NotesInhibits ROKa/ROCK II, PRK2, MSK1, Rsk2, PKA, p70 S6 Kinase, CaM Kinase and MLCK.
Biological Information
Entrez Gene Number
Entrez Gene SummaryThis gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.
Gene Symbol
  • ROCK2
  • KIAA0619
Protein TargetRho kinase 2
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q16513 # Exhibits a preference for highly basic protein substrates (By similarity).
SIZE: 984 amino acids; 112035 Da
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
DOMAIN:SwissProt: Q16513 The C1 domain does not bind the diacylglycerol (DAG).
PTM: Autophosphorylated. & Activated by limited proteolysis with trypsin (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 1 protein kinase domain. & Contains 3 REM (Hr1) repeats.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions1 year at 4°C
Packaging Information
Material Size5 mg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
19-164 04053252728730

Powiązane produkty i zastosowania

Product Families

Kinase & Phosphatase Products

Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
Dowiedz się więcej >>

Kategorie

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors
Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase G (PKG; cGMP-Dependent Protein Kinase) Inhibitors