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324674 EGFR Inhibitor - CAS 879127-07-8 - Calbiochem

The EGFR Inhibitor, also referenced under CAS 879127-07-8, controls the biological activity of EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

EGFR Inhibitor - CAS 879127-07-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Cyclopropanecarboxylic acid-(3-(6-(3-trifluoromethyl-phenylamino)-pyrimidin-4-ylamino)-phenyl)-amide

Primary Target: EGFR
324674
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Przegląd

Replacement Information

Tabela kluczowych gatunków

CAS #Empirical Formula
879127-07-8C₂₁H₁₈F₃N₅O

Products

Numer katalogowyOpakowanie Ilość/opak.
324674-1MG Ampulka plastikowa 1 mg
Description
OverviewA cell-permeable 4,6-dianilinopyrimidine compound that acts as a potent, ATP-competitive, and highly selective inhibitor of EGFR and some EGFR mutants (IC50 = 21 nM, 63 nM, and 4 nM for EGFRwt, EGFRL858R and EGFRL861Q, respectively) vs. erbB4/Her4 (IC50 = 7.64 µM) and a panel of 55 other kinases. Shown to completely block EGF-induced EGFR autophosphorylation in U-2OS cells at 10 µM.
Catalogue Number324674
Brand Family Calbiochem®
SynonymsCyclopropanecarboxylic acid-(3-(6-(3-trifluoromethyl-phenylamino)-pyrimidin-4-ylamino)-phenyl)-amide
References
ReferencesZhang, Q., et al. 2006. J. Am. Chem. Soc. 128, 2182
Product Information
CAS number879127-07-8
ATP CompetitiveY
FormOff-white solid
Hill FormulaC₂₁H₁₈F₃N₅O
Chemical formulaC₂₁H₁₈F₃N₅O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetEGFR
Primary Target IC<sub>50</sub>21 nM, 63 nM, and 4 nM for EGFRwt, EGFRL858R and EGFRL861Q, respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
324674-1MG 04055977196764

Documentation

EGFR Inhibitor - CAS 879127-07-8 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

EGFR Inhibitor - CAS 879127-07-8 - Calbiochem Certificates of Analysis

TitleLot Number
324674

References

Przegląd literatury
Zhang, Q., et al. 2006. J. Am. Chem. Soc. 128, 2182

Posters

Title
Human Kinome & InhibitorSelect™ Libraries
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-September-2007 JSW
SynonymsCyclopropanecarboxylic acid-(3-(6-(3-trifluoromethyl-phenylamino)-pyrimidin-4-ylamino)-phenyl)-amide
DescriptionA cell-permeable 4,6-dianilinopyrimidine compound that acts as a potent, ATP-competitive, and highly selective inhibitor of EGFR and some EGFR mutants (IC50 = 21 nM, 63 nM, and 4 nM for EGFRwt, EGFRL858R and EGFRL861Q, respectively) vs. erbB4/Her4 (IC50 = 7.64 µM) and a panel of 55 other kinases. Shown to completely block EGF-induced EGFR autophosphorylation in U-2OS cells at 10 µM.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number879127-07-8
Chemical formulaC₂₁H₁₈F₃N₅O
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml) or Ethanol (25 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesZhang, Q., et al. 2006. J. Am. Chem. Soc. 128, 2182