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234115 Colchicine, Colchicum autumnale - CAS 64-86-8 - Calbiochem

Colchicine, Colchicum autumnale, CAS 64-86-8, is an inhibitor of mitosis that disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in PC12 and cerebellar granule cells.

Colchicine, Colchicum autumnale - CAS 64-86-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Inhibitor of mitosis
234115
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Przegląd

Replacement Information

Tabela kluczowych gatunków

CAS #Empirical Formula
64-86-8C₂₂H₂₅NO₆

Products

Numer katalogowyOpakowanie Ilość/opak.
234115-1GM Beben aluminiowy 1 gm
234115-5GM 5 gm
Description
OverviewInhibitor of mitosis that is useful in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in PC12 cells and in cerebellar granule cells.
Catalogue Number234115
Brand Family Calbiochem®
References
ReferencesBonfoco, E., et al. 1995. Exp. Cell Res. 218, 189.
Lindenboim, L., et al. 1995. J. Neurochem. 64, 1054.
Leung, M.F., and Sartorelli, A.C. 1992. Leuk. Res. 16, 929.
Santell, L. 1992. Exp. Cell Res. 201, 358.
Salmon, E.D., et al. 1984. J. Cell Biol. 99, 1066.
Product Information
CAS number64-86-8
ATP CompetitiveN
FormYellow or off-white powder
Hill FormulaC₂₂H₂₅NO₆
Chemical formulaC₂₂H₂₅NO₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetInhibitor of mitosis
Purity≥94% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSGH0700000
Safety Information
R PhraseR: 26/28

Very toxic by inhalation and if swallowed.
S PhraseS: 13-45

Keep away from food, drink and animal feeding stuffs.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
234115-1GM 07790788048839
234115-5GM 07790788048846

Documentation

Colchicine, Colchicum autumnale - CAS 64-86-8 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Colchicine, Colchicum autumnale - CAS 64-86-8 - Calbiochem Certificates of Analysis

TitleLot Number
234115

References

Przegląd literatury
Bonfoco, E., et al. 1995. Exp. Cell Res. 218, 189.
Lindenboim, L., et al. 1995. J. Neurochem. 64, 1054.
Leung, M.F., and Sartorelli, A.C. 1992. Leuk. Res. 16, 929.
Santell, L. 1992. Exp. Cell Res. 201, 358.
Salmon, E.D., et al. 1984. J. Cell Biol. 99, 1066.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-October-2009 RFH
DescriptionMajor alkaloid of Colchicum autumnale. Inhibitor of mitosis used in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in pheochromocytoma (PC12) cells and in cerebellar granule cells.
FormYellow or off-white powder
CAS number64-86-8
RTECSGH0700000
Chemical formulaC₂₂H₂₅NO₆
Structure formulaStructure formula
Purity≥94% by HPLC
SolubilityEthanol (10 mg/ml) or H₂O
Storage Protect from light
+15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Merck USA index14, 2471
ReferencesBonfoco, E., et al. 1995. Exp. Cell Res. 218, 189.
Lindenboim, L., et al. 1995. J. Neurochem. 64, 1054.
Leung, M.F., and Sartorelli, A.C. 1992. Leuk. Res. 16, 929.
Santell, L. 1992. Exp. Cell Res. 201, 358.
Salmon, E.D., et al. 1984. J. Cell Biol. 99, 1066.