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400015 Caspase-1 Inhibitor IV - CAS 154674-81-4 - Calbiochem

400015
Purchase on Sigma-Aldrich

Przegląd

Replacement Information

Tabela kluczowych gatunków

CAS #Empirical Formula
154674-81-4C₃₃H₄₂N₄O₁₀

Products

Numer katalogowyOpakowanie Ilość/opak.
400015-1MG Ampulka plastikowa 1 mg
Description
OverviewA highly selective, competitive, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.
Catalogue Number400015
Brand Family Calbiochem®
SynonymsICE Inhibitor IV, Ac-YVAD-AOM
References
ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.
Product Information
CAS number154674-81-4
ATP CompetitiveN
FormWhite solid
Hill FormulaC₃₃H₄₂N₄O₁₀
Chemical formulaC₃₃H₄₂N₄O₁₀
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcaspase-1
Purity≥96% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceAc-Tyr-Val-Ala-Asp-AOM (AOM = 2,6-dimethylbenzoyloxymethyl ketone)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
400015-1MG 07790788049935

Documentation

Caspase-1 Inhibitor IV - CAS 154674-81-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Caspase-1 Inhibitor IV - CAS 154674-81-4 - Calbiochem Certificates of Analysis

TitleLot Number
400015

References

Przegląd literatury
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-April-2011 RFH
SynonymsICE Inhibitor IV, Ac-YVAD-AOM
DescriptionHighly selective, competitive and irreversible inhibitor of caspase-1 and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles, such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.
FormWhite solid
CAS number154674-81-4
Chemical formulaC₃₃H₄₂N₄O₁₀
Peptide SequenceAc-Tyr-Val-Ala-Asp-AOM (AOM = 2,6-dimethylbenzoyloxymethyl ketone)
Structure formulaStructure formula
Purity≥96% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from moisture
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.