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203811 Bryostatin 1 - CAS 83314-01-6 - Calbiochem

A macrocyclic lactone with antitumor properties.

Bryostatin 1 - CAS 83314-01-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Bryo 1, PKC Activator VII, PKC Activator VI

Primary Target: Protein kinase C
203811
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Przegląd

Tabela kluczowych gatunków

CAS #Empirical Formula
83314-01-6C₄₇H₆₈O₁₇

Products

Numer katalogowyOpakowanie Ilość/opak.
203811-10UG Ampulka plastikowa 10 μg
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Description
OverviewA macrocyclic lactone with antitumor properties. Potently activates protein kinase C and exhibits a high binding affinity (Ki = 1.35 nM). Effectively translocates and down-regulates PKC isozymes α, δ, and ε. Induces a biphasic activation of PKD through a PKC-dependent pathway in intact cells. Also shown to activate Ras in Jurkat T cells and in rat2 cells.
Catalogue Number203811
Brand Family Calbiochem®
SynonymsBryo 1, PKC Activator VII, PKC Activator VI
References
ReferencesClamp, A., and Jayson, G. 2002. Anticancer Drugs 13, 673.
Lorenzo, P.S., et al. 1999. Cancer Res. 59, 6137.
Wang, Q.J., et al. 1999. J. Biol. Chem. 274, 37233.
Wender, P.A., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 6624.
Matthews, S.A., et al. 1997. J. Biol. Chem. 272, 20245.
Szallasi, Z., et al. 1994. Mol. Pharmacol. 46, 840.
Berkow, R.L., and Kratt, A.S. 1985. Biochem. Biophys. Res. Commun. 3, 1109.
Product Information
CAS number83314-01-6
ATP CompetitiveN
FormWhite to colorless solid or film
Hill FormulaC₄₇H₆₈O₁₇
Chemical formulaC₄₇H₆₈O₁₇
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetProtein kinase C
Primary Target K<sub>i</sub>1.35 nM for protein kinase C
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Safety Information according to GHS
RTECSEH9455000
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Global Trade Item Number
Numer katalogowy GTIN
203811-10UG 04055977204025