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504314 Bortezomib - CAS 179324-69-7 - Calbiochem

504314
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Tabela kluczowych gatunków

CAS #Empirical Formula
179324-69-7C₁₉H₂₅BN₄O₄

Products

Numer katalogowyOpakowanie Ilość/opak.
5043140001 Butelka szklana 5 mg
Description
OverviewA cell-permeable dipeptidylboronate compound that selectively inhibits 20S proteasome β5 ChTL/chymotrypsin- over β1 CL/caspase- and β2 TL/trypsin-like activity (kinact/Ki = 38,000, 5,700, and <100 M-1s-1, respectively, in human 20S proteasome assays using 10 µM Suc-LLVY-AMC/Cat. No. 539142, 10 µM Z-LLE-AMC/Cat. No. 539141, or 50 µM Boc-LRR-AMC as substrate) via a covalent, slowly reversible manner, displaying much reduced potency against human chymotrypsin, cathepsin G, leukocyte elastase, and thrombin (Ki = 0.32, 0.63, 2.3, and 13 µM, respectively, vs. 620 nM using rabbit muscle 20S). A widely used inhibitor both in cultures in vitro and in animals in vivo.
Catalogue Number504314
Brand Family Calbiochem®
Synonyms(R)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid, Proteasome Inhibitor XXII, PS-341, MG-341, Pyz-Phe-boroLeu, BTZ, LDP-341, LDP341, MG341, MLN-341, MLN341, PS341
References
ReferencesDu, X.L, and Chen, Q. 2013. Acta Haematol. 129, 207.
Tamatani, T., et al. 2013. Int. J. Oncol. 42, 935.
Beck, P., et al. 2012. J. Biol. Chem. 393, 1101.
Fang, H.T., et al. 2012. Proc. Natl. Acad. Sci. USA. 109, 2521.
Chen, D., et al. 2011. Curr. Cancer Drug Targets 11, 239.
Demo, S.D., et al. 2007. Cancer Res. 67, 6383.
Adams, J., et al. 1999. Cancer Res. 59, 2615.
Teicher, B.A., et al. 1999. Clin. Cancer Res. 5, 2638.
Adams, J., et al. 1998. Bioorg. Med. Chem. Lett. 8, 333.
Product Information
CAS number179324-69-7
FormOff-white solid
Hill FormulaC₁₉H₂₅BN₄O₄
Chemical formulaC₁₉H₂₅BN₄O₄
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationBortezomib, CAS 179324-69-7, is a cell-permeable, selective, slowly reversible inhibitor of 20S proteasome β5 ChTL/chymotrypsin- over β1 CL/caspase- and β2 TL/trypsin-like activity.
Biological Information
Primary Target20S proteasome
Purity≥98% by LC-MS
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C.) Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Numer katalogowy GTIN
5043140001 04055977263923