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197331 Bcl-2 Inhibitor II, YC137 - CAS 810659-53-1 - Calbiochem

197331
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Tabela kluczowych gatunków

CAS #Empirical Formula
810659-53-1C₂₄H₂₁N₃O₆S₂

Products

Numer katalogowyOpakowanie Ilość/opak.
197331-5MG Butelka szklana 5 mg
Description
OverviewA cell-permeable naphthoquinone compound that selectively induces apoptosis of Bcl-2-overexpressing cells (< 300 nM in MDA-MB435B breast cancer cells) with little effect on a variety of primary cells, and Bcl-xL-dependent cells, even at a concentration of 5 µM. Preferentially binds Bcl-2 (Ki = 1.3 µM) and disrupts its interaction with Bid BH3, thereby blocking the anti-apoptotic activity of Bcl-2. Shown to induce the release of cytochrome c from mitochondria and activate caspase-9.
Catalogue Number197331
Brand Family Calbiochem®
Synonyms2-Methoxycarbonylamino-4-methylsulfanyl-butyric acid, 4-(4,9-dioxo-4,9-dihydronaphtho[2,3-d]thiazol-2-ylamino)-phenyl ester
References
ReferencesReal, P.J., et al. 2004. Cancer Res. 64, 7947.
Product Information
CAS number810659-53-1
ATP CompetitiveN
FormRed solid
Hill FormulaC₂₄H₂₁N₃O₆S₂
Chemical formulaC₂₄H₂₁N₃O₆S₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetBcl-2
Primary Target K<sub>i</sub>1.3 µM in binding Bcl-2
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Numer katalogowy GTIN
197331-5MG 04055977206081