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16-235 Sigma-AldrichAnti-phospho-erbB-2/HER-2 (Tyr1248) Antibody, Alexa Fluor® 488

This Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody, Alexa Fluor 488 is validated for use in FC, IC for the detection of phospho-erbB-2/HER-2 (Tyr1248).

Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody, Alexa Fluor® 488 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Research Category: Signaling Research Sub-Category: Growth Factors & Receptors, Kinases & Phosphatases Gene Symbol: ERBB2, HER2, HER-2, NGL, herstatin, erbB-2, C-erbB-2, NEU, TKR1, p185erbB2, HER-2/neu UniProt Number: P04626

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Tabela kluczowych gatunków

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, R	FC, ICC	Rb	AlexaFluor®488	Polyclonal Antibody

Description
Catalogue Number	16-235
Brand Family	Upstate
Trade Name	Upstate
Description	Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody, Alexa Fluor® 488

References

Product Information
Format	AlexaFluor®488
Quality Level	MQ100

Applications
Application	This Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody, Alexa Fluor 488 is validated for use in FC, IC for the detection of phospho-erbB-2/HER-2 (Tyr1248).
Key Applications	Flow Cytometry Immunocytochemistry

Biological Information
Immunogen	Synthetic phosphopeptide, residues 1243-1255, corresponding to a major autophosphorylation (Tyr1248) site of human Erb B2/HER-2 (C-AENPEpYLGLDVPV)
Host	Rabbit
Specificity	the activated form of Erb B2/HER-2 oncoprotein
Isotype	IgG
Species Reactivity	Human Rat
Species Reactivity Note	Predicted to cross react with rat based on conservation of immunogenic sequence
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_001005862.1 NM_004448.2
Entrez Gene Summary	This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Gene Symbol	ERBB2 HER2 HER-2 NGL herstatin erbB-2 C-erbB-2 NEU TKR1 p185erbB2 HER-2/neu
Modifications	Phosphorylation
Purification Method	ImmunoAffinity Purified
UniProt Number	P04626
UniProt Summary	FUNCTION: SwissProt: P04626 # Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF- alpha and amphiregulin. SIZE: 1255 amino acids; 137910 Da SUBUNIT: Heterodimer with each of the other ERBB receptors (Potential). Interacts with PRKCABP and PLXNB1. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with MEMO when phosphorylated on Tyr-1248. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. PTM: Ligand-binding increases phosphorylation on tyrosine residues (By similarity). SIMILARITY: SwissProt: P04626 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.
Molecular Weight	185kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Routinely evaluated by immunostaining of EGF treated A431 cells
Usage Statement	Alexa Fluor® is a registered trademark of Molecular Probes, Inc. Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Product Usage Statements

Quality Assurance

Routinely evaluated by immunostaining of EGF treated A431 cells

Usage Statement

Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	1 year at 4°C from date of shipment

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Numer katalogowy	GTIN
16-235	04053252507663

Documentation

Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody, Alexa Fluor® 488 MSDS

Title
Safety Data Sheet (SDS)

Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody, Alexa Fluor® 488 Certificates of Analysis

Title	Lot Number
Anti-phospho-erbB-2/HER-2 (Tyr1248), Alexa Fluor#174; 488 conjugate (rabbit immunoaffinity purified IgG) - 2108474	2108474
Anti-phospho-erbB-2/HER-2 (Tyr1248), Alexa Fluor#174; 488 conjugate - DAM1567754	DAM1567754
Anti-phospho-erbB-2/HER-2 (Tyr1248), Alexa Fluor#174; 488 conjugate - JBC1920618	JBC1920618
Anti-phospho-erbB-2/HER-2 (Tyr1248), Alexa Fluorreg; 488 conjugate - 30489	30489
Anti-phospho-erbB-2/HER-2 (Tyr1248), Alexa Fluorreg; 488 conjugate - 33437	33437
Anti-phospho-erbB-2/HER-2 (Tyr1248), Alexa Fluor® 488 conjugate (rabbit immunoaffinity purified IgG) - 2424085	2424085
Anti-phospho-erbB-2/HER-2 (Tyr1248), Alexa Fluor® 488 conjugate - 3171756	3171756
Anti-phospho-erbB-2/HER-2 (Tyr1248), Alexa Fluor® 488 conjugate - 3919695	3919695
Anti-phospho-erbB-2/HER-2 (Tyr1248), Alexa Fluor® 488 conjugate -2547169	2547169
Anti-phospho-erbB-2/HER-2 (Tyr1248), Alexa Fluor® 488 conjugate -2630274	2630274

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Kategorie

Life Science Research > Antibodies and Assays > Primary Antibodies

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