Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

MABF220 Anti-mA20 Antibody/TNFAIP3, clone 37

Detect mA20/TNFAIP3 using this Anti-mA20 Antibody/TNFAIP3, clone 37 validated for use in flow cytometry.

Anti-mA20 Antibody/TNFAIP3, clone 37 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Apoptosis - Additional Gene Symbol: Tnfaip3, Tnfip3 UniProt Number: Q60769
MABF220
100 µg  
Purchase on Sigma-Aldrich

Oferty specjalne

Przegląd

Replacement Information

Oferty specjalne

100% Performance Guaranteed

Tabela kluczowych gatunków

Species ReactivityKey ApplicationsHostFormatAntibody Type
MFCRPurifiedMonoclonal Antibody
Description
Catalogue NumberMABF220
DescriptionAnti-mA20 Antibody/TNFAIP3, clone 37
Alternate Names
  • Tumor necrosis factor alpha-induced protein 3
  • TNF alpha-induced protein 3
  • Putative DNA-binding protein A20
  • Zinc finger protein A20
Background InformationTNFAIP3/mA20, also known as Tumor necrosis factor alpha-induced protein 3, OTU domain-containing protein 7C, Putative DNA-binding protein A20, or Zinc finger protein A20, and encoded by the gene TNFAIP3/OTUD7C, is an ubiquitin editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. TNFAIP3/mA20 is involved in immune and inflammatory responses signaled by cytokines or pathogens through the Toll-like receptors and ultimately regulating NF-kappa-B activity. TNFAIP3/mA20 is an essential component of the ubiquitin editing protein complex consisting of RNF11, ICTH, and TAX1BP1 and ensures the transient nature of inflammatory signaling. TNFAIP3/mA20 is also a key player in switching of Lys-63 polyubiquitinated chains to Lys-48 polyubiquitinated chains for the subsequent degradation of specific targets as well. TNFAIP3/mA20 is located in the cytoplasm but can be found in the nucleus and lysosome depending upon the microenvironment and stimulus.
References
Product Information
FormatPurified
PresentationPurified rat monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect mA20/TNFAIP3 using this Anti-mA20 Antibody/TNFAIP3, clone 37 validated for use in flow cytometry.
Key Applications
  • Flow Cytometry
Biological Information
ImmunogenRecombinant protein corresponding to Mouse mA20/TNFAIP3.
Clone37
Concentration0.5 mg/mL
HostRat
IsotypeIgMκ
Species Reactivity
  • Mouse
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • Tnfaip3
  • Tnfip3
Purification MethodPurified by Ion-Exchange Chromatography
UniProt Number
Molecular Weight90 kDa calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Flow Cytometry in mouse splenocytes.

Flow Cytometry Analysis: 2 µg of this antibody detected mA20/TNFAIP3 in 1X10E6 mouse splenocytes.

This antibody was produced in collaboration with the Scripps Research Institute.For Scripps Research Institute Validation (Click Here)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
MABF220 04053252977848