Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

09-007 Anti-acetyl STAT5B (Lys694) Antibody

Anti-acetyl STAT5B (Lys694) Antibody is a Rabbit Polyclonal Antibody for detection of acetyl STAT5B (Lys694) also known as Signal transducer & activator of transcription 5B & has been validated in DB & WB.

Anti-acetyl STAT5B (Lys694) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: Stat5b UniProt Number: P42232
09-007
100 µg  
Purchase on Sigma-Aldrich

Oferty specjalne

Przegląd

Replacement Information

Oferty specjalne

100% Performance Guaranteed

Tabela kluczowych gatunków

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RDB, WBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue Number09-007
DescriptionAnti-acetyl STAT5B (Lys694) Antibody
Alternate Names
  • Signal transducer and activator of transcription 5B
Background InformationSTAT5B (signal transducers and activators of transcription 5b) controls the expression of early response genes and takes part in cytokine signaling. Studies have linked this protein to the inhibition of NFkappaB-mediated signaling. Additional studies have shown an association of STAT5B with regulation of lactation and growth, performance, and control of adipocyte function. Constitutively active STAT5B expression is often observed in a large number of leukemia’s and solid tumors.
References
Product Information
FormatAffinity Purified
Control
  • Modified and non modified peptides of acetylated and non-acetylated STAT5B protein
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-acetyl STAT5B (Lys694) Antibody is a Rabbit Polyclonal Antibody for detection of acetyl STAT5B (Lys694) also known as Signal transducer & activator of transcription 5B & has been validated in DB & WB.
Key Applications
  • Dot Blot
  • Western Blotting
Application NotesWestern Blot Analysis: A representative lot was used by an independent laboratory in WB. (Ma, L., et al. (2010). Proc Natl Acad Sci U S A. 107(45):19314-19319.)
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to mouse STAT5B acetylated at Lys694.
EpitopeAcetylated Lys694
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes STAT5B acetylated at Lys694.
Species Reactivity
  • Human
  • Mouse
  • Rat
Species Reactivity NoteDemonstrated to react with Human. Predicted to react with Rat based on 100% sequence homology. Predicted to react with Mouse based on immunogen design.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • Stat5b
Modifications
  • Acetylation
Purification MethodAffinity Purfied
UniProt Number
UniProt SummaryFUNCTION: Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.

SUBUNIT STRUCTURE: Forms a homodimer or a heterodimer with a related family member. Interacts with SOCS7 By similarity. Binds NR3C1 and NCOA1.

SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note: Translocated into the nucleus in response to phosphorylation.

TISSUE SPECIFICITY: In the virgin, found in most tissues. Particularly abundant in muscle tissue of virgin and lactating females, and of males.

DEVELOPMENTAL STAGE: Detected both in virgin mouse and after mammary gland involution. The level of STAT5A increases constantly during pregnancy, but decreases during lactation.

PTM: Tyrosine phosphorylated.

POLYMORPHISM: The polymorphism at position 327 in strain NOD reduces DNA-binding affinity.

SEQUENCE SIMILARITIES: Belongs to the transcription factor STAT family.

Contains 1 SH2 domain.
Molecular Weight90 kDa calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Dot Blot in modified and non modified peptides of acetylated and non-acetylated STAT5B protein.

Dot Blot Analysis: 1 µg/mL of this antibody detected STAT5B in modified and non modified peptides of acetylated and non-acetylated STAT5B protein.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
09-007 04053252684494