Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

MAB5566 Anti-Tubulin α Antibody, detyrosinated

MAB5566
100 µL  
Purchase on Sigma-Aldrich

Oferty specjalne

Przegląd

Oferty specjalne

Tabela kluczowych gatunków

Species ReactivityKey ApplicationsHostFormatAntibody Type
MaWBMAscitesMonoclonal Antibody
Description
Catalogue NumberMAB5566
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Tubulin α Antibody, detyrosinated
Product Information
FormatAscites
PresentationLiquid. Contains no preservative.
Quality LevelMQ100
Applications
ApplicationThis Anti-Tubulin Antibody, α, detyrosinated is validated for use in WB for the detection of Tubulin.
Key Applications
  • Western Blotting
Application Notes(add note)
Biological Information
ImmunogenSynthetic peptide GEEEGE.
Epitopedetyrosinated
HostMouse
SpecificityAlpha tubulin, detyrosinated.
IsotypeIgG2a
Species Reactivity
  • Mammals
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryMicrotubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to mouse and rat Tuba1 gene. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.
Gene Symbol
  • TUBA1A
  • hum-a-tub2
  • LIS3
  • FLJ25113
  • TUBA3
  • B-ALPHA-1
  • hum-a-tub1
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q71U36 # Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
SIZE: 451 amino acids; 50136 Da
SUBUNIT: Dimer of alpha and beta chains.
PTM: Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively (By similarity).
SIMILARITY: SwissProt: Q71U36 ## Belongs to the tubulin family.
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size100 µL
Global Trade Item Number
Numer katalogowy GTIN
MAB5566 04053252610677