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AB15570-I Anti-Tryptophan hydroxylase 1/TPH1 Antibody

This Anti-Tryptophan hydroxylase 1/TPH1 antibody is validated for use in western blotting & IHC (Paraffin) for the detection of Tryptophan hydroxylase 1/TPH1.

Anti-Tryptophan hydroxylase 1/TPH1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: Tph1, Tph UniProt Number: P09810
AB15570-I
100 µg  
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Tabela kluczowych gatunków

Species ReactivityKey ApplicationsHostFormatAntibody Type
MWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB15570-I
ReplacesAB15570
DescriptionAnti-Tryptophan hydroxylase 1/TPH1 Antibody
Alternate Names
  • Tryptophan 5-hydroxylase 1
  • Tryptophan 5-monooxygenase 1
Background InformationTryptophan hydroxylase 1/TPH1, also known as Tryptophan 5-hydroxylase 1, also known as Tryptophan 5-monooxygenase 1, and encoded by the gene TPH1/TPH/TPRH/TRPH, is an important biosynthetic enzyme needed for serotonin synthesis from L-trytophan. TPH1 is responsible for the addition of the -OH grouip to 5-hydroxytryptophan which is the initial and rate limiting step in the synthesis of serotonin. Serotonin in a neurotransmitter and has an antidepressant effect on the brain. The activity of TPH1 is also modulated by phosphorylation Protein Kinase A is responsible for the phosphorylation of TPH1 and helps to modulate its activity in neurons. TPH1 is mostly expressed in tissues that express serotonin such as the brain, pineal gland, and CNS but also can be found in skin and intestinal tissues.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-Tryptophan hydroxylase 1/TPH1 antibody is validated for use in western blotting & IHC (Paraffin) for the detection of Tryptophan hydroxylase 1/TPH1.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:50-500 dilution from a representative lot detected Tryptophan hydroxylase 1/TPH1 in mouse pancreas and mouse colon tissue.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Tryptophan hydroxylase 1/TPH1 in mouse cerebellum and mouse cerebral cortex tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of rat Tryptophan hydroxylase 1/TPH1.
EpitopeC-terminus
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Mouse
Species Reactivity NoteMouse. Predicted to react with Rat based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • Tph1
  • Tph
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~51 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in P815 cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected Tryptophan hydroxylase 1/TPH1 in 10 µg of P815 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
AB15570-I 04053252961069

Documentation

Anti-Tryptophan hydroxylase 1/TPH1 Antibody MSDS

Title

Safety Data Sheet (SDS) 

Anti-Tryptophan hydroxylase 1/TPH1 Antibody Certificates of Analysis

TitleLot Number
Anti-Tryptophan hydroxylase 1/TPH1 - Q2388158 Q2388158
Anti-Tryptophan hydroxylase 1/TPH1 - 3227307 3227307
Anti-Tryptophan hydroxylase 1/TPH1 - 3742323 3742323
Anti-Tryptophan hydroxylase 1/TPH1 - 3928041 3928041
Anti-Tryptophan hydroxylase 1/TPH1 - 4163456 4163456
Anti-Tryptophan hydroxylase 1/TPH1 -2659586 2659586
Anti-Tryptophan hydroxylase 1/TPH1 -2700258 2700258
Anti-Tryptophan hydroxylase 1/TPH1 -2753824 2753824
Anti-Tryptophan hydroxylase 1/TPH1 Polyclonal Antibody 2953851
Anti-Tryptophan hydroxylase 1/TPH1 Polyclonal Antibody 3089573