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ABN647 Anti-Syntaphilin Antibody

Anti-Syntaphilin Antibody is an antibody against Syntaphilin for use in western blotting, IHC & immunofluorescence.

Anti-Syntaphilin Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: SNPH, KIAA0374 UniProt Number: O15079
ABN647
100 µg  
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Tabela kluczowych gatunków

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHC, IFRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABN647
DescriptionAnti-Syntaphilin Antibody
Alternate Names
  • Syntaphilin
Background InformationSyntaphilin (SNPH) is a single-pass membrane protein that was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait. Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25. Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis. Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis. Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria. This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Syntaphilin Antibody is an antibody against Syntaphilin for use in western blotting, IHC & immunofluorescence.
Key Applications
  • Western Blotting
  • Immunohistochemistry
  • Immunofluorescence
Application NotesImmunohistochemistry Analysis: 5 μg/mL from a representative lot detected Syntaphilin in human brain tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected Syntaphilin in human brain cells.
Biological Information
ImmunogenKLH-conjugated synthetic peptide corresponding to the center region of human Syntaphilin.
Epitopecenter region
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Gene Symbol
  • SNPH
  • KIAA0374
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~86 kDa observed. Uncharacterized bands may be observed in some lysate(s). Despite its predicted molecular weight, Syntaphilin usually migrates at higher molecular weight in SDS-PAGE.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 2 μg/mL of this antibody detected Syntaphilin in rat brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
ABN647 04053252946660