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MABN349 Anti-Synaptotagmin-12 Antibody (SYT12), clone 1B12.1

This Anti-Synaptotagmin-12 Antibody (SYT12), clone 1B12.1 is validated for use in Western Blotting for the detection of Synaptotagmin-12 (SYT12).

Anti-Synaptotagmin-12 Antibody (SYT12), clone 1B12.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: SYT12 UniProt Number: Q8IV01
MABN349
100 µg  
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Tabela kluczowych gatunków

Species ReactivityKey ApplicationsHostFormatAntibody Type
R, HWBMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABN349
DescriptionAnti-Synaptotagmin-12 Antibody (SYT12), clone 1B12.1
Alternate Names
  • Synaptotagmin-12
  • Synaptotagmin XII
  • SytXII
  • Synaptotagmin-12 (SYT12)
Background InformationSynaptotagmin-12 (SYT12) , also known as Synaptotagmin-12, Synaptotagmin XII, SytXII, and encoded by the gene SYT12, is an important protein involved in calcium dependent exocytosis of secretory vesicles through calcium and phospholipid binding to the C2 domain and Synaptotagmin-12 may serve as calcium sensors in the process of vesicular trafficking and exocytosis. Synaptotagmin-12 is a synaptic vesicle phosophoprotein that modulates spontaneous neurotransmitter release, but unlike other family members Synaptotagmin-12 differs from classical synaptotagmins in that it does not bind Ca(2+). In synaptic vesicles, synaptotagmin-12 forms a complex with synaptotagmin-1 that prevents synaptotagmin-1 from interacting with SNARE complexes. Synaptotagmin-12 also is an abundant synaptic vesicle protein that is important in LTP transmission. For instance, its phosphorylation by cAMP Protein Kinase is necessary for hippocampal mossy fiber LTP.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-Synaptotagmin-12 Antibody (SYT12), clone 1B12.1 is validated for use in Western Blotting for the detection of Synaptotagmin-12 (SYT12).
Key Applications
  • Western Blotting
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to the cytoplasmic domain of human Synaptotagmin-12 (SYT12).
EpitopeCytoplasmic domain
Clone1B12.1
Concentration0.5 mg/mL
HostMouse
IsotypeIgG1κ
Species Reactivity
  • Rat
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • SYT12
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~ 47 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Synaptotagmin-12 (SYT12) in 200 µg of rat brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
MABN349 04053252978784