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16-321 Sigma-AldrichAnti-Ras Magnetic Bead Conjugate Antibody

Anti-Ras Magnetic Bead Conjugate Antibody detects level of Ras Magnetic Bead Conjugate & has been published & validated for use in WB & IP.

Anti-Ras Magnetic Bead Conjugate Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA

Research Category: Signaling Research Sub-Category: MAP Kinases, G-proteins Gene Symbol: K-Ras, Ki-Ras, K-Ras2, Kras-2, p21B, KRAS, RASK2, HRAS, HA_RAS, N-RAS, H-RAS, NRAS, NRAS1, ALPS4 UniProt Number: P01116

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Tabela kluczowych gatunków

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, R, M	WB, IP	M	Purified	Monoclonal Antibody

Description
Catalogue Number	16-321
Description	Anti-Ras Magnetic Bead Conjugate Antibody
Alternate Names	GTP- and GDP-binding peptide B GTPase Hras Ha-Ras1 proto-oncoprotein Ras family small GTP binding protein H-Ras Transforming protein p2 c-has/bas p21 protein c-ras-Ki-2 activated oncogene p19 H-RasIDX protein transformation gene: oncogene HAMSV v-Ha-ras Harvey rat sarcoma viral oncogene homolog
Background Information	The tumor oncoproteins HRas, KRas, and NRas are rated as Ras protoncogenes. Point mutations within Ras genes are frequently detected in human malignancies and in experimentally induced tumors in animals.

References

Product Information
Format	Purified
Control	A431 whole cell lysate
Presentation	20% slurry; 1xPBS, 0.05% sodium azide. Sufficient for 10 immunoprecipitation assays.
Quality Level	MQ100

Applications
Application	Anti-Ras Magnetic Bead Conjugate Antibody detects level of Ras Magnetic Bead Conjugate & has been published & validated for use in WB & IP.
Key Applications	Western Blotting Immunoprecipitation
Application Notes	Immunoprecipitation: 150 μg of this antibody has been reported to immunoprecipitate Ras.

Biological Information
Immunogen	KLH-conjugated protein corresponding to human Ras.
Host	Mouse
Specificity	This antibody recognizes p21H-, K- and N-Ras.
Isotype	IgG2aκ
Species Reactivity	Human Rat Mouse
Species Reactivity Note	Proven to react with human, mouse and rat. Other species unknown.
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_203524
Entrez Gene Summary	Members of the RAS superfamily of GTP-binding proteins, which includes MRAS, are membrane-anchored, intracellular signal transducers responsible for a variety of normal cellular functions. They are oncogenically activated in a significant fraction of tumors.[supplied by OMIM]
Gene Symbol	K-Ras Ki-Ras K-Ras2 Kras-2 p21B KRAS RASK2 HRAS HA_RAS N-RAS H-RAS NRAS NRAS1 ALPS4
Purification Method	Protein G Purified
UniProt Number	P01116
UniProt Summary	FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Enzyme regulation:Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). SIZE: 189 amino acids; 21,656 Da SUBUNIT: Interacts with PHLPP (By similarity). SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. Involvement in disease: Defects in KRAS are a cause of acute myelogenous leukemia (AML) [MIM:601626]. AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development. Defects in KRAS are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. It is characterized by leukocytosis with tissue infiltration and in vitro hypersensitivity of myeloid progenitors to granulocyte-macrophage colony stimulating factor. Defects in KRAS are the cause of Noonan syndrome 3 (NS3) [MIM:609942]. Noonan syndrome (NS) [MIM:163950] is a disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incidence of 1 in 1000-2500 live births. Rarely, NS is associated with juvenile myelomonocytic leukemia (JMML). NS3 inheritance is autosomal dominant. Defects in KRAS are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant. KRAS mutations are involved in cancer development.
Molecular Weight	21 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8ºC from date of receipt. DO NOT FREEZE

Packaging Information
Material Size	200 µL

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Numer katalogowy	GTIN
16-321	04053252751271

Documentation

Anti-Ras Magnetic Bead Conjugate Antibody MSDS

Title
Safety Data Sheet (SDS)

Anti-Ras Magnetic Bead Conjugate Antibody Certificates of Analysis

Title	Lot Number
Anti-Ras Magnetic Bead Conjugate	2487770
Anti-Ras Magnetic Bead Conjugate	2483268
Anti-Ras Magnetic Bead Conjugate - 2051389	2051389
Anti-Ras Magnetic Bead Conjugate - 2377629	2377629
Anti-Ras Magnetic Bead Conjugate - 2514586	2514586
Anti-Ras Magnetic Bead Conjugate - 3201051	3201051
Anti-Ras Magnetic Bead Conjugate - 3290995	3290995
Anti-Ras Magnetic Bead Conjugate - 3561574	3561574
Anti-Ras Magnetic Bead Conjugate - 3610577	3610577
Anti-Ras Magnetic Bead Conjugate - 3759064	3759064

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Kategorie

Life Science Research > Antibodies and Assays > Primary Antibodies

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