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AB9708 Anti-PSD-95 Antibody

AB9708
100 µg  
Purchase on Sigma-Aldrich

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Replacement Information

Oferty specjalne

Tabela kluczowych gatunków

Species ReactivityKey ApplicationsHostFormatAntibody Type
RWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB9708
Replaces04-1066
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-PSD-95 Antibody
Alternate Names
  • Post synaptic density 95
References
Product Information
FormatAffinity Purified
PresentationLiquid in PBS with 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-PSD-95 Antibody detects level of PSD-95 & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Application NotesWestern blot: 0.1-1 μg/mL on rat brain microsomal preparation.

Optimal working dilutions must be determined by the end user.
Biological Information
ImmunogenSynthetic peptide.
HostRabbit
SpecificityPSD-95 (Post synaptic density 95). By Western blot the antibody recognizes a band at ~95 kDa in rat brain microsomal preparation.
Species Reactivity
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with DLG2. With DLG2 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.
Gene Symbol
  • DLG4
  • SAP90
  • PSD-95
  • PSD95
Purification MethodImmunoAffinity Purified
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P78352 # Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ACCN3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
SIZE: 724 amino acids; 80495 Da
SUBUNIT: Interacts through its first two PDZ domains with GRIN2A, GRIN2B, GRIN2C, GRIN2D, ACCN3, certain splice forms of GRIN1, KCND2, CXADR and SYNGAP1. Interacts through its second PDZ domain with the PDZ domain of NOS1 or the C-terminus of CAPON. May interact with HTR2A. Interacts through its guanylate kinase-like domain with DLGAP1/GKAP, DLGAP2, DLGAP3, DLGAP4, MAP1A, and BEGAIN (By similarity). Interacts through its first two PDZ domains with KCNA1, KCNA2, KCNA3, KCNA4 and ERBB4. Interacts through its first PDZ domain with GRIK2, KCNA4 and CRIPT. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with KIF13B. Isoform 2 interacts through an L27 domain with HGS/HRS and the first L27 domain of CASK.
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells.
TISSUE SPECIFICITY: Brain.
DOMAIN: SwissProt: P78352 The PDZ domain 3 mediates interaction with ADR1B. & The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to post-synaptic density.
PTM: Palmitoylation of isoform 1 is required for targeting to postsynaptic density (By similarity).
SIMILARITY: Belongs to the MAGUK family. & Contains 1 guanylate kinase-like domain. & Contains 3 PDZ (DHR) domains. & Contains 1 SH3 domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
AB9708 04053252368219

Documentation

Anti-PSD-95 Antibody MSDS

Title

Safety Data Sheet (SDS) 

Anti-PSD-95 Antibody Certificates of Analysis

TitleLot Number
RABBIT ANTI-PSD-95 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2455687 2455687
RABBIT ANTI-PSD-95 - 3218980 3218980
RABBIT ANTI-PSD-95 - 3311793 3311793
RABBIT ANTI-PSD-95 - 3466605 3466605
RABBIT ANTI-PSD-95 - 3723442 3723442
RABBIT ANTI-PSD-95 - 3833730 3833730
RABBIT ANTI-PSD-95 - 4006263 4006263
RABBIT ANTI-PSD-95 - 4066557 4066557
RABBIT ANTI-PSD-95 - 4191768 4191768
RABBIT ANTI-PSD-95 -2717653 2717653

References

Reference overviewApplicationPub Med ID
Repeated neonatal propofol administration induces sex-dependent long-term impairments on spatial and recognition memory in rats.
Gonzales, EL; Yang, SM; Choi, CS; Mabunga, DF; Kim, HJ; Cheong, JH; Ryu, JH; Koo, BN; Shin, CY
Biomolecules & therapeutics  23  251-60  2015

Pokaż streszczenie
25995824 25995824
MET receptor tyrosine kinase controls dendritic complexity, spine morphogenesis, and glutamatergic synapse maturation in the hippocampus.
Qiu, S; Lu, Z; Levitt, P
The Journal of neuroscience : the official journal of the Society for Neuroscience  34  16166-79  2014

Pokaż streszczenie
Immunohistochemistry25471559 25471559
REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors.
Rodenas-Ruano, A; Chávez, AE; Cossio, MJ; Castillo, PE; Zukin, RS
Nature neuroscience  15  1382-90  2011

Pokaż streszczenie
22960932 22960932
Effects of food restriction and sucrose intake on synaptic delivery of AMPA receptors in nucleus accumbens.
Peng XX, Ziff EB, Carr KD
Synapse  2010

Pokaż streszczenie
21425350 21425350

Data Sheet

Title
RABBIT ANTI-PSD-95 AFFINITY PURIFIED

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Product Families

Kategorie

Life Science Research > Antibodies and Assays > Primary Antibodies