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ABC517 Anti-PGAM5 Antibody

This Anti-PGAM5 Antibody is validated for use in Western Blotting for the detection of PGAM5.

Anti-PGAM5 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: PGAM5 UniProt Number: Q96HS1
ABC517
100 µg  
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Tabela kluczowych gatunków

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABC517
DescriptionAnti-PGAM5 Antibody
Alternate Names
  • Serine/threonine-protein phosphatase PGAM5, mitochondrial
  • Bcl-XL-binding protein v68
  • Phosphoglycerate mutase family member 5
Background InformationPGAM5 is a mitochondrial specific phosphatase specific for serine/threonine residues. PGAM5 principally dephosphorylates and activates MAP3K5 kinase a critical player in many cancers. PGAM5 also acts as a central mediator for programmed necrosis or necroptosis, induced by TNF, ROS or calcium. In the mitochondria, PGAM5 may also function as a regulator of mitochondrial dynamics and reconstruction. Also PGAM5 functions in the cellular stress response and regulates the removal of damaged mitochondria via mitophagy. PGAM5 itself is regulated at the protein level by the mitochondrial specific rhomboid protease PARL, which cleaves the N-terminal of PGAM5 in response to mitochondrial depolarization.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-PGAM5 Antibody is validated for use in Western Blotting for the detection of PGAM5.
Key Applications
  • Western Blotting
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human PGAM5 near the N-terminal.
EpitopeNear N-terminal
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityThis antibody detects the -L(long) isoform and -S(short) isoform of PGAM5.
Species Reactivity
  • Human
Species Reactivity NoteHuman. Predicted to react with Monkey, Chimpanzee, Primate, Rodent, Hamster based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • PGAM5
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~32/34 kDa observed.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in HT-29 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected PGAM5 in 10 µg of HT-29 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
ABC517 04053252986413