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MABS519 Anti-P40 Antibody, clone 11F12.1

Anti-P40 Antibody, clone 11F12.1 is an antibody against P40 for use in IHC (Paraffin) & western blotting.

Anti-P40 Antibody, clone 11F12.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: TP63, KET, P63, P73H, P73L, TP73L UniProt Number: Q9H3D4
MABS519
100 µg  
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Tabela kluczowych gatunków

Species ReactivityKey ApplicationsHostFormatAntibody Type
HIH(P), WBMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABS519
DescriptionAnti-P40 Antibody, clone 11F12.1
Alternate Names
  • Tumor protein 63
  • p63
  • Chronic ulcerative stomatitis protein
  • CUSP
  • Keratinocyte transcription factor KET
  • Transformation-related protein 63
  • TP63
  • Tumor protein p73-like
  • p73L
  • p40
  • p51
Background InformationP40, also known as Tumor protein 63, p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor , KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, p40, or p51, and encoded by the gene TP63/KET/P63/P73H/P73L/TP73L, is a transcriptional activator or repressor depending upon the target gene and the isoform involved. P40 has multiple isoforms. P40 is involved in Notch signaling and plays a role in p53/TP53 dependent apoptosis and epithelial morphogenesis. Moreover P40, developmentally, is required for proper limb formation. P40 is widely expressed in the adult and during development. Some isoforms, such as isoform 10 are primarily expressed in cancerous tissues while others are found only in normal tissues. Mutations in P40 lead to a variety of dysplasias and malformations, including Acro-dermato-ungual-lacrimal-tooth syndrome and Ankyloblepharon-ectodermal defects cleft lip/palate disorder and several more tragic disfiguring syndromes.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-P40 Antibody, clone 11F12.1 is an antibody against P40 for use in IHC (Paraffin) & western blotting.
Key Applications
  • Immunohistochemistry (Paraffin)
  • Western Blotting
Application NotesImmunohistochemistry Analysis: A 1:500-2,000 dilution from a representative lot detected P40 in human prostate and human kidney tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human P40.
Clone11F12.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG2aκ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • TP63
  • KET
  • P63
  • P73H
  • P73L
  • TP73L
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~40 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in SK-OV-3 cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected P40 in 10 µg of SK-OV-3 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
MABS519 04053252977862