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AB15514 Anti-Neuroligin 3 Antibody

This Anti-Neuroligin 3 Antibody is validated for use in WB, IH, ELISA for the detection of Neuroligin 3.

Anti-Neuroligin 3 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Synapse & Synaptic Biology Gene Symbol: NLGN3, HNL3, NL3, AUTSX1, ASPGX1, KIAA1480 UniProt Number: Q9NZ94
AB15514
50 µg  
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Tabela kluczowych gatunków

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHC, ELISARbPurifiedPolyclonal Antibody
Description
Catalogue NumberAB15514
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Neuroligin 3 Antibody
Background InformationNeuroligins are Type I membrane proteins enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. They have been characterized as neuronal cell surface proteins and are thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. They play a major role in the formation or maintenance of synaptic junctions. They are also thought to be involved in the specification of excitatory synapses. Neuroligins interact with beta-neurexins and this interaction is involved in the formation of functional synapses.
References
Product Information
FormatPurified
PresentationLiquid in PBS with 0.1% BSA and 0.05% sodium azide
Quality LevelMQ100
Applications
ApplicationThis Anti-Neuroligin 3 Antibody is validated for use in WB, IH, ELISA for the detection of Neuroligin 3.
Key Applications
  • Western Blotting
  • Immunohistochemistry
  • ELISA
Application NotesWestern blot: 1-10 μg/mL using ECL.
Immunohistochemistry: Not tested. It is recommended that the antibody be tried at 2-20 μg/mL
ELISA: 1:10,000-1:100,000 using 50-100 ng of control peptide/well.
Optimal working dilutions must be determined by end user.
Biological Information
ImmunogenSynthetic peptide near the C-terminus of human Neuroligin 3
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityNeuroligin 3 (NLGN3)
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but their full length sequences have not been determined.
Gene Symbol
  • NLGN3
  • HNL3
  • NL3
  • AUTSX1
  • ASPGX1
  • KIAA1480
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q9NZ94 # Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. May play a role in formation or maintenance of synaptic junctions. May also play a role in glia- glia or glia-neuron interactions in the developing peripheral nervous system.
SIZE: 848 amino acids; 93895 Da
SUBUNIT: Interacts with neurexin 1-beta, neurexin 2-beta and neurexin 3-beta (By similarity). Probably interacts through its C- terminus with DLG4/PSD-95 third PDZ domain.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
DISEASE: SwissProt: Q9NZ94 # Defects in NLGN3 may be the cause of susceptibility to X- linked autism 1 (AUTSX1) [MIM:300425]. AUTSX1 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. & Defects in NLGN3 may be the cause of susceptibility to X- linked Asperger syndrome 1 (ASPGX1) [MIM:300494]. ASPGX1 is considered to be a form of childhood autism.
SIMILARITY: SwissProt: Q9NZ94 ## Belongs to the type-B carboxylesterase/lipase family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size50 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
AB15514 04053252408854

Documentation

Anti-Neuroligin 3 Antibody MSDS

Title

Safety Data Sheet (SDS) 

Anti-Neuroligin 3 Antibody Certificates of Analysis

TitleLot Number
RABBIT ANTI-NEUROLIGIN 3 - 3192410 3192410
RABBIT ANTI-NEUROLIGIN 3 -2621533 2621533
RABBIT ANTI-NEUROLIGIN 3 -2686222 2686222
RABBIT ANTI-NEUROLIGIN 3 -2686869 2686869
RABBIT ANTI-NEUROLIGIN 3 -2689179 2689179
RABBIT ANTI-NEUROLIGIN 3 -2768759 2768759
RABBIT ANTI-NEUROLIGIN 3 -2803660 2803660
RABBIT ANTI-NEUROLIGIN 3 AFFNITY PURIFIED POLYCLONAL ANTIBODY 3026853
RABBIT ANTI-NEUROLIGIN 3 AFFNITY PURIFIED POLYCLONAL ANTIBODY - 2019780 2019780
RABBIT ANTI-NEUROLIGIN 3 AFFNITY PURIFIED POLYCLONAL ANTIBODY - 2041587 2041587
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Data Sheet

Title
RABBIT ANTI-NEUROLIGIN 3 AFFNITY PURIFIED POLYCLONAL ANTIBODY