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MAB5260-60UG Anti-Nerve Growth Factor Antibody, clone 27/21

MAB5260-60UG
60 µg  
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Tabela kluczowych gatunków

Species ReactivityKey ApplicationsHostFormatAntibody Type
B, H, M, RELISAMPurifiedMonoclonal Antibody
Description
Catalogue NumberMAB5260-60UG
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Nerve Growth Factor Antibody, clone 27/21
Alternate Names
  • NGF
Product Information
FormatPurified
PresentationPurified immunoglobulin. Lyophilized from 0.02M Phosphate buffer, 0.25M NaCl with 0.1% sodium azide. Reconstitute with 1 mL of sterile distilled water.
Quality LevelMQ100
Applications
ApplicationThis Anti-Nerve Growth Factor Antibody, clone 27/21 is validated for use in ELISA for the detection of Nerve Growth Factor.
Key Applications
  • ELISA
Application NotesELISA

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen2.5 S form of mouse NGF.
Clone27/21
HostMouse
SpecificityNGF is a neurotrophic protein which is synthesized by the target tissues of NGF-sensitive neurons. NGF acts on sympathetic and sensoric neurons as well as on cholinergic neurons of the basal forebrain. It has been suggested that NGF is involved in the neuropathology of Alzheimer's Disease (Hefti & Weiner, 1986). In the peripheral nervous system, NGF plays a role in the development of autonomic and sensory neuropathies (Anand et al., 1991).

The antibody specifically reacts with the beta -subunit of NGF from mouse, in the 2.5S- as well as in the 7S-form.

The cross-reactivity with human NGF is 60-90 % of the reactivity with mouse NGF
IsotypeIgG1
Species Reactivity
  • Bovine
  • Human
  • Mouse
  • Rat
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.
Gene Symbol
  • NTF3
  • NT3
  • NGF2
  • HDNF
  • MGC129711
  • NGF-2
  • NT-3
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P20783 # Seems to promotes the survival of visceral and proprioceptive sensory neurons.
SIZE: 257 amino acids; 29355 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Brain and peripheral tissues.
SIMILARITY: SwissProt: P20783 ## Belongs to the NGF-beta family.
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsThe lyophilized antibody is stable if stored dry at 2-8°C for up to 12 months. After reconstitution maintain at 4°C unaliquotted but sealed tightly for 6 months; do not freeze thaw.
Packaging Information
Material Size60 µg
Global Trade Item Number
Numer katalogowy GTIN
MAB5260-60UG 04053252318757