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MAB3314 Anti-MMP-16 Antibody, clone 117-10C6

Anti-MMP-16 Antibody, clone 117-10C6 detects level of MMP-16 & has been published & validated for use in WB.

Anti-MMP-16 Antibody, clone 117-10C6 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: MMPs & TIMPs Gene Symbol: MMP16, MMPX2, MMP-16, MT3MMP, MT-MMP3, MT3-MMP, MTMMP3, MMP-X2, MT-MMP2, EC 3.4.24.- UniProt Number: P51512
MAB3314
100 µg  
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Tabela kluczowych gatunków

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBMPurifiedMonoclonal Antibody
Description
Catalogue NumberMAB3314
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-MMP-16 Antibody, clone 117-10C6
Alternate Names
  • MT3-MMP
References
Product Information
FormatPurified
PresentationLiquid in 0.1 M sodium phosphate buffer, pH 7.0 containing 2% protease free bovine serum albumin.
Quality LevelMQ100
Applications
ApplicationAnti-MMP-16 Antibody, clone 117-10C6 detects level of MMP-16 & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Application NotesImmunoblotting
Biological Information
ImmunogenThis antibody was made to an oligopeptide of EEVPYSELENGKRD (residue 168-181) on human membrane-type 3 matrix metalloproteinase (human MT3-MMP).
Clone117-10C6
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityThe antibody specifically reacts with human MT3-MMP. This is a purified mouse monoclonal antibody to an oligopeptide of EEVPYSELENGKRD (residue 168-181) on human membrane-type 3 matrix metalloproteinase (human MT3-MMP).
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene produces at least two transcripts, one which encodes a membrane-bound form and another a soluble form of the protein. Both forms of the protein activate MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16.
Gene Symbol
  • MMP16
  • MMPX2
  • MMP-16
  • MT3MMP
  • MT-MMP3
  • MT3-MMP
  • MTMMP3
  • MMP-X2
  • MT-MMP2
  • EC 3.4.24.-
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P51512 # Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. The short isoform cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
COFACTOR: Binds 1 zinc ion per subunit (By similarity). & Calcium (By similarity).
SIZE: 607 amino acids; 69521 Da
SUBUNIT: Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.
SUBCELLULAR LOCATION: Isoform Long: Cell membrane; Single-pass type I membrane protein (Potential). Note=Localized at the cell surface of melanoma cells. & Isoform Short: Secreted. Cell surface. Note=Localized at the cell surface of melanoma cells.
TISSUE SPECIFICITY: Expressed in heart, brain, placenta, ovary and small intestine. The short isoform is found in the ovary.DEVELOPMENTAL STAGE: Expressed in tissues undergoing reconstruction. Present in fetal tissues, especially in brain. Expression seems to decline with advanced development.
DOMAIN: SwissProt: P51512 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
PTM: The precursor is cleaved by a furin endopeptidase (By similarity).
SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Availability by Geography
  • This product is not available for sale in Japan.
Usage Statement
  • Manufactured by Daiichi Fine Chemical Co., Ltd
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain frozen at -20°C in undiluted aliquots for up to 12 months.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
MAB3314 04053252663079

Documentation

Anti-MMP-16 Antibody, clone 117-10C6 MSDS

Title

Safety Data Sheet (SDS) 

Anti-MMP-16 Antibody, clone 117-10C6 Certificates of Analysis

TitleLot Number
MOUSE ANTI-HUMAN- MT3-MMP 3170776
MOUSE ANTI-HUMAN- MT3-MMP MONOCLONAL ANTIBODY - 2442557 2442557
MOUSE ANTI-HUMAN- MT3-MMP - 3205432 3205432
MOUSE ANTI-HUMAN- MT3-MMP - 3221939 3221939
MOUSE ANTI-HUMAN- MT3-MMP -2567484 2567484
MOUSE ANTI-HUMAN- MT3-MMP -2615122 2615122
MOUSE ANTI-HUMAN- MT3-MMP -2641139 2641139
MOUSE ANTI-HUMAN- MT3-MMP -2684250 2684250
MOUSE ANTI-HUMAN- MT3-MMP -2691550 2691550
MOUSE ANTI-HUMAN- MT3-MMP -2743589 2743589
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