Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

AB5663P Anti-Histamine Receptor 4 Antibody, CT

Anti-Histamine Receptor 4 Antibody, C-terminus detects level of Histamine Receptor 4 & has been published & validated for use in ELISA & WB.

Anti-Histamine Receptor 4 Antibody, CT MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Inflammation & Autoimmune Mechanisms Gene Symbol: HRH4, H4R, MGC133027, GPCR105, HH4R, GPRv53, H4, AXOR35, SP9144, BG26 UniProt Number: Q9H3N8
AB5663P
50 µg  
Purchase on Sigma-Aldrich

Oferty specjalne

Przegląd

Replacement Information

Oferty specjalne

100% Performance Guaranteed

Tabela kluczowych gatunków

Species ReactivityKey ApplicationsHostFormatAntibody Type
HELISA, WBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB5663P
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Histamine Receptor 4 Antibody, CT
Alternate Names
  • H4R
References
Product Information
FormatAffinity Purified
PresentationAffinity purified immunoglobulin. Liquid in PBS with 0.1% BSA.
Quality LevelMQ100
Applications
ApplicationAnti-Histamine Receptor 4 Antibody, C-terminus detects level of Histamine Receptor 4 & has been published & validated for use in ELISA & WB.
Key Applications
  • ELISA
  • Western Blotting
Application NotesWestern blot: 1-10 μg/mL using ECL.

ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well (Catalog number AG217).

Optimal working dilutions must be determined by the end user.
Biological Information
ImmunogenA 17 amino acid peptide sequence within the cytoplasmic, C-terminus of human HR4 (Oda et al. 2000; Nakamura et al. 2000).
EpitopeC-terminus
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityRecognizes human Histamine Receptor 4 (HR4). The immunogen shows no significant sequence homology with other histamine receptors.
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryHistamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H4 belongs to the family 1 of G protein-coupled receptors and has the highest homology to histamine receptor H3 among known G protein-coupled receptors.
Gene Symbol
  • HRH4
  • H4R
  • MGC133027
  • GPCR105
  • HH4R
  • GPRv53
  • H4
  • AXOR35
  • SP9144
  • BG26
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q9H3N8 # The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
SIZE: 390 amino acids; 44496 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, fetal liver and lymph node.
SIMILARITY: SwissProt: Q9H3N8 ## Belongs to the G-protein coupled receptor 1 family.
MISCELLANEOUS: Does not bind diphenhydramine, loratadine, ranitidine, cimetidine and chlorpheniramine. Shows modest affinity for dimaprit, impromidine, clobenpropit, thioperamide, burimamide clozapine, immepip and imetit. The order of inhibitory activity was imetit > clobenpropit > burimamide > thioperamide. Clobenpropit behaves as a partial agonist, dimaprit and impromidine show some agonist activity while clozapine behaves as a full agonist. Thioperamide shows inverse agonism (enhances cAMP activity). The order of inhibitory activity of histamine derivatives was Histamine > N-alpha-methylhistamine > R(-)-alpha- methylhistamine > S(+)-alpha-methylhistamine. Both N-alpha- methylhistamine > R(-)-alpha-methylhistamine behave as full agonists.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size50 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
AB5663P 04053252367687

Documentation

Anti-Histamine Receptor 4 Antibody, CT MSDS

Title

Safety Data Sheet (SDS) 

Anti-Histamine Receptor 4 Antibody, CT Certificates of Analysis

TitleLot Number
RABBIT ANTI-HISTAMINE RECEPTOR 4 (HR4) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2386936 2386936
RABBIT ANTI-HISTAMINE RECEPTOR 4 (HR4) - 3197708 3197708
RABBIT ANTI-HISTAMINE RECEPTOR 4 (HR4) - 3209791 3209791
RABBIT ANTI-HISTAMINE RECEPTOR 4 (HR4) - 4154489 4154489
RABBIT ANTI-HISTAMINE RECEPTOR 4 (HR4) AFFINITY PURIFIED POLYCLONAL ANTIBODY 2956214
RABBIT ANTI-HISTAMINE RECEPTOR 4 (HR4) AFFINITY PURIFIED POLYCLONAL ANTIBODY 2918422
RABBIT ANTI-HISTAMINE RECEPTOR 4 (HR4) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2006043 2006043
RABBIT ANTI-HISTAMINE RECEPTOR 4 (HR4) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2179314 2179314
RABBIT ANTI-HISTAMINE RECEPTOR 4 (HR4) AFFINITY PURIFIED POLYCLONAL ANTIBODY - PSO1565998 PSO1565998