Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

AB10532 Anti-GABA(A) receptor subunit gamma-2 Antibody

This Anti-GABA(A) receptor subunit gamma-2 Antibody is validated for use in WB for the detection of GABA(A) receptor subunit gamma-2.

Anti-GABA(A) receptor subunit gamma-2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: GEFSP3, CAE2, ECA2, GABRG2 UniProt Number: P18508
AB10532
100 µL  
Purchase on Sigma-Aldrich

Oferty specjalne

Przegląd

Replacement Information

Oferty specjalne

100% Performance Guaranteed

Tabela kluczowych gatunków

Species ReactivityKey ApplicationsHostFormatAntibody Type
R, HWBRbSerumPolyclonal Antibody
Description
Catalogue NumberAB10532
DescriptionAnti-GABA(A) receptor subunit gamma-2 Antibody
Alternate Names
  • gamma-aminobutyric acid (GABA) A receptor, gamma 2
  • gamma-aminobutyric acid A receptor, gamma 2
  • GABA(A) receptor subunit gamma-2
Background InformationGABA(A) receptor subunit gamma-2 is a protein belonging to a subclass of GABA receptors known as GABA (A). GABA (A) receptors are pentameric chloride channels composed of subunits belonging to different homology classes, i.e. α, β, γ, δ, θ, ε, π, and act as receptors for GABA, a crucial inhibitory neurotransmitter localized within the brain. GABA (A) gamma 2 subunit consists of 5 cysteine residues and carries the binding site for benzodiazepine. The subunit functions to promote receptor maintenance and clustering at the synapse, interacts with GABA receptor associated proteins such as GODZ and GABAWRAP, affects GABA (A) receptor conductance and kinetics, and is a contributing component to receptors participating in both phasic and tonic inhibition. Several mutations in the GABA(A) receptor subunit gamma-2 expression have been linked to epileptic syndromes that result in fibrile seizures.
References
Product Information
FormatSerum
Control
  • PC12 cell lysate
PresentationRabbit polyclonal serum containing 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-GABA(A) receptor subunit gamma-2 Antibody is validated for use in WB for the detection of GABA(A) receptor subunit gamma-2.
Key Applications
  • Western Blotting
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to rat GABA(A) receptor subunit gamma-2.
HostRabbit
SpecificityThis antibody recognizes GABA(A) receptor subunit gamma-2.
Species Reactivity
  • Rat
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummarySubunit of GABA receptors, which bind benzodiazepines and act as inhibitory ion channels in the brain [RGD].
Gene Symbol
  • GEFSP3
  • CAE2
  • ECA2
  • GABRG2
Purification MethodUnpurified
UniProt Number
UniProt SummaryFUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

SUBUNIT STRUCTURE: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

SUBCELLULAR LOCATION: Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

PTM: Palmitoylated by ZDHHC3/GODZ; which may affect presynaptic clustering and/or cell surface stability (By similarity).

MISCELLANEOUS: This subunit carries the benzodiazepine binding site.

SEQUENCE SIMLARITIES: Belongs to the ligand-gated ionic channel (TC 1.A.9) family. (View classification)
Molecular Weight~60 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in PC12 cell lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected GABA(A) receptor subunit gamma-2 on 10 µg of PC12 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
AB10532 04053252478802

Documentation

Anti-GABA(A) receptor subunit gamma-2 Antibody MSDS

Title

Safety Data Sheet (SDS) 

Anti-GABA(A) receptor subunit gamma-2 Antibody Certificates of Analysis

TitleLot Number
Anti-GABA(A) receptor subunit -2550894 2550894
Anti-GABA(A) receptor subunit gamma-2 - 2445044 2445044
Anti-GABA(A) receptor subunit gamma-2 - 2039821 2039821
Anti-GABA(A) receptor subunit gamma-2 - 3691429 3691429
Anti-GABA(A) receptor subunit gamma-2 - 3808722 3808722
Anti-GABA(A) receptor subunit gamma-2 - NG1881286 NG1881286
Anti-GABA(A) receptor subunit gamma-2 - NRG1781528 NRG1781528