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MABN851 Anti-CRALBP Antibody, clone 3H9.1

Anti-CRALBP Antibody, clone 3H9.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Sensory & PNS Gene Symbol: RLBP1, CRALBP UniProt Number: P12271
MABN851
100 μg  
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Tabela kluczowych gatunków

Species ReactivityKey ApplicationsHostFormatAntibody Type
MWBMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABN851
DescriptionAnti-CRALBP Antibody, clone 3H9.1
Alternate Names
  • Retinaldehyde-binding protein 1
  • Cellular retinaldehyde-binding protein
  • CRALBP
Background InformationRetinaldehyde-binding protein 1 (UniProt P12271; also known as Cellular retinaldehyde-binding protein) is encoded by the RLBP1 (also known as CRALBP) gene (Gene ID 6017) in human. CRALBP is a retinoid-binding protein expressed in retinal pigment epithelial (RPE) cells and Müller glia involved in the retinal visual cycle. Photoactivation of a visual pigment molecule in vertebrate rod and cone photoreceptors renders the pigment molecule into a bleached all-trans retinal form, which must be exported out of the photoreceptors to be converted back to the light-sensitive 11-cis retinal form in RPE cells (for both rods and cones) or in retinal Müller glia (for cones only). The 11-cis chromophore is then imported back into photoreceptors, where it combines with a free opsin to regenerate the visual pigment. CRALBP is a 36 kDa water-soluble protein that facilitates the intracellular transport of hydrophobic 11-cis retinoids. Mutations in human RLBP1 cause several autosomal recessive retinal diseases, such as retinitis pigmentosa, Bothnia dystrophy, retinitis punctata albescens, fundus albipunctatus, and Newfoundland rod-cone dystrophy. Likewise, Rlbp1-knockout mice exhibit M-opsin mislocalization, M-cone loss, and impaired cone-driven visual behavior and light responses. Viral expression of CRALBP in Müller cells, but not RPE cells, is reported to rescue the retinal visual cycle and M-cone sensitivity in Rlbp1-knockout mice.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
Key Applications
  • Western Blotting
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to the N-terminal half of human CRALBP.
EpitopeN-terminal half.
Clone3H9.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG1κ
Species Reactivity
  • Mouse
Species Reactivity NoteMouse. Predicted to react with Human based on 100% sequence homology.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • RLBP1
  • CRALBP
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~36 kDa observed.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in mouse retina tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected CRALBP in 10 µg of mouse retina tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
MABN851 04055977311822