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ABF200 Anti-Bst2 Antibody

Detect Bone marrow stromal antigen 2 using this rabbit polyclonal antibody, Anti-Bst2 Antibody validated for use in western blotting.

Anti-Bst2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Immunological Signaling Gene Symbol: Bst2, BST-2, BST2 UniProt Number: Q8R2Q8
ABF200
100 µg  
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Tabela kluczowych gatunków

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABF200
ReplacesMABF201
DescriptionAnti-Bst2 Antibody
Alternate Names
  • Bone marrow stromal cell antigen 2
  • BST-2
  • CD317
  • HM1.24 antigen
Background InformationBone marrow stromal cell antigen 2 (BST-2, Bst2), also known as CD317, and HM1.24 antigen, is an IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian viruses by directly tethering nascent virions to the membranes of infected cells. Bst2 has been shown to interact with various viruses, including: human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae: ebola virus (EBOV), arenaviridae: lassa virus (LASV), and rhabdoviridae: vesicular stomatitis virus (VSV). Bst2 may inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Additionally, it is implied to interact with LILRA4/ILT7, which results in providing negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. This activity suggests that Bst2 can provide a potential therapeutic strategy for the treatment of HIV/AIDS. Bst2 may play a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells
References
Product Information
FormatAffinity Purified
Control
  • Human placenta tissue
PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect Bone marrow stromal antigen 2 using this rabbit polyclonal antibody, Anti-Bst2 Antibody validated for use in western blotting.
Key Applications
  • Western Blotting
Application NotesWestern Blotting Analysis: 2 µg/mL from a representative lot detected Bst2 in 15 µg of Daudi cell lysate.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the N-terminus of mouse Bst2.
EpitopeN-terminus
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes the N-terminus of Bst2.
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Gene Symbol
  • Bst2
  • BST-2
  • BST2
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~22 kDa observed. Uncharacterized bands may appear in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry in human placenta tissue.

Immunohistochemistry Analysis: A 1:250 dilution of this antibody detected Bst2 in human placenta tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
ABF200 04053252912283