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ABC1484 Anti-Bcl-B Antibody

This Anti-Bcl-B Antibody is validated for use in Western Blotting_x000D_ and Immunocytochemistry for the detection of Bcl-B.

Anti-Bcl-B Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: BCL2L10, BCLB UniProt Number: Q9HD36
ABC1484
100 μg  
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Tabela kluczowych gatunków

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, ICCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABC1484
DescriptionAnti-Bcl-B Antibody
Alternate Names
  • Bcl-2-like protein 10
  • Bcl2-L-10
  • Anti-apoptotic protein NrH
  • Apoptosis regulator Bcl-B
  • Bcl-B
Background InformationThe protein named Bcl-2-like protein 10 (Bcl2-L-10) or alternatively Anti-apoptotic protein NrH or Apoptosis regulator Bcl-B, and encoded by the human gene BCL2L10/BCLB is member of the BcL2 anti-apoptosis family and promotes cell survival by suppressing the actions of BAX and BAK in destabilizing the mitochondrial membrane potential leading to apoptosis activation. Bcl-B can interact with Bcl-2, BcL2L1/BCL-XL, and BAX. It is expressed in the cytoplasm and interacts primarily at the mitochondrial membranes. Bcl-B is abundantly expressed in human embryos prior to implantation and was predominantly cytoplasmic with localization at the mitochondria in normal embryos. In abnormal embryos Bcl-B was outside the mitochondria as well as nuclear located, but the exact nature of the role of Bcl-B in abnormal embryos is still be elucidated. Interestingly, Bcl-B because of its anti-apoptotic effects is also the cause for anti-cancer drug resistance and it is used a marker for potential drug failures in anti-cancer therapy.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing PBS (pH 7.2) with 0.02% sodium azide.
Quality LevelMQ300
Applications
ApplicationThis Anti-Bcl-B Antibody is validated for use in Western Blotting_x000D_ and Immunocytochemistry for the detection of Bcl-B.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application NotesImmunocytochemistry Analysis (ICC): 10 μg/mL from a representative lot detected Bcl-B in Jurkat cells.
Biological Information
ImmunogenBcl-B antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human Bcl-B.
EpitopeNear N-terminus
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Gene Symbol
  • BCL2L10
  • BCLB
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~40 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in Jurkat cell lysate.

Western Blotting Analysis (WB): 1 μg/mL of this antibody detected Bcl-B in Jurkat cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
ABC1484 04055977174618