Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

AB9574 Anti-BACE2 Antibody

This Anti-BACE2 Antibody is validated for use in IP, WB for the detection of BACE2.

Anti-BACE2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: BACE2, ALP56, ASP1, DRAP, memapsin-1, APL56, CEAP1, BAE2, Memapsin-1, Asp1, CDA13, AEPLC, ASP21, EC 3.4.23.45 UniProt Number: Q9Y5Z0
AB9574
100 µL  
Purchase on Sigma-Aldrich

Oferty specjalne

Przegląd

Replacement Information

Oferty specjalne

100% Performance Guaranteed

Tabela kluczowych gatunków

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RIP, WBRbSerumPolyclonal Antibody
Description
Catalogue NumberAB9574
ReplacesAB5834
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-BACE2 Antibody
References
Product Information
FormatSerum
PresentationRabbit serum. Liquid.
Quality LevelMQ100
Applications
ApplicationThis Anti-BACE2 Antibody is validated for use in IP, WB for the detection of BACE2.
Key Applications
  • Immunoprecipitation
  • Western Blotting
Application NotesWestern blot: 1:2,000. The antibody recognizes the ~64 kDa BACE2 protein in HEK293, SHSy5y, N2A and PC12 cell lysate.

Immunoprecipitation

Optimal working dilutions must be determined by the end user.
Biological Information
ImmunogenSynthetic peptide from the C-terminus of human BACE2.
HostRabbit
SpecificityThe antibody recognizes the BACE2 protein.
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryCerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.
Gene Symbol
  • BACE2
  • ALP56
  • ASP1
  • DRAP
  • memapsin-1
  • APL56
  • CEAP1
  • BAE2
  • Memapsin-1
  • Asp1
  • CDA13
  • AEPLC
  • ASP21
  • EC 3.4.23.45
UniProt Number
UniProt SummarySIZE: 518 amino acids; 56180 Da
SUBUNIT: Interacts ith RTN3 and RTN4.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: Q9Y5Z0 ## Belongs to the peptidase A1 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
AB9574 04053252364020