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PC150 Anti-β-Amyloid (1-42) Rabbit pAb

This Anti-β-Amyloid (1-42) Rabbit pAb is validated for use in Dot Blot, ELISA, Radioimmunoassay for the detection of β-Amyloid (1-42).

Anti-β-Amyloid (1-42) Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
PC150
Purchase on Sigma-Aldrich

Przegląd

Replacement Information

Tabela kluczowych gatunków

Species ReactivityHostAntibody Type
HRbPolyclonal Antibody

Products

Numer katalogowyOpakowanie Ilość/opak.
PC150-25UG Ampulka plastikowa 25 μg
Description
OverviewRecognizes specifically β-amyloid peptide (1-42). Does not cross-react with β-amyloid peptide (1-40) or β-amyloid peptide (1-43).
  • Antibody Target Gene Symbol: APP
  • Target Synonym: AAA, AD1, Adap, AL024401, Amyloid precursor, Amyloidogenic glycoprotein, APP isoform 1, APPI, appican, CTFgamma, CVAP, E030013M08RIK, Nexin II, P3, PN2, PreA4, PROTEASE NEXIN2
  • Entrez Gene Name: amyloid beta (A4) precursor protein
  • Hu Entrez ID: 351 (Related Antibodies: 171610, PC729,PC152, PC151, PC149, NE1012,171609, 171608, 171607, 171606, 171605, 171604, 171603, 171598, 171537)
  • Mu Entrez ID: 11820
  • Rat Entrez ID: 54226
    		•
    Catalogue NumberPC150
    Brand Family Calbiochem®
    References
    ReferencesSavage, M.J., et al. 1998. J. Neurosci. 15, 1743.
    Borchelt, D.R., et al. 1997. Neuron 19, 939.
    Citron, M., et al. 1997. Nature Med. 3, 67.
    Hardy, J. 1997. Trends in Neurosci. 20, 154.
    Solomon, B., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 4109.
    Duff, K., et al. 1996. Nature 383, 710.
    Iwatsubo, T., et al. 1994. Neuron 13, 45.
    Suzuki, N., et al. 1994. Science 264, 133.
    Product Information
    FormLiquid
    FormulationIn phosphate buffer, pH 7.4.
    PreservativeNone
    Quality LevelMQ100
    Applications
    Key Applications Dot Blot
    Enzyme-Linked Immunosorbent Assay
    Radioimmunoassay
    Application NotesDot Blot (0.1-0.5 µg/ml)
    ELISA (0.1-0.5 µg/ml)
    Radioimmunoassay (0.5 µg/ml)
    Application CommentsThis antibody is specific for β-amyloid peptide [1-42] and shows no reactivity to β-amyloid peptide [1-40] or β-amyloid peptide [1-43]. This antibody is recommended for use in the quantitative determination of β-amyloid peptide [1-42]. The sensitivity level for sandwich ELISA is 15-25 pg. Antibody should be titrated for optimal results in individual systems.
    Biological Information
    Immunogena synthetic peptide corresponding to amino acids from a C-terminal fragment of human β-amyloid peptide (1-42)
    ImmunogenHuman
    HostRabbit
    IsotypeIgG
    Species Reactivity
    • Human
    Antibody TypePolyclonal Antibody
    Concentration Label Please refer to vial label for lot-specific concentration
    Physicochemical Information
    Dimensions
    Materials Information
    Toxicological Information
    Safety Information according to GHS
    Safety Information
    Product Usage Statements
    Storage and Shipping Information
    Ship Code Dry Ice Only
    Toxicity Standard Handling
    Storage -20°C
    Avoid freeze/thaw Avoid freeze/thaw
    Do not freeze Ok to freeze
    Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
    Packaging Information
    Transport Information
    Supplemental Information
    Specifications
    Global Trade Item Number
    Numer katalogowy GTIN
    PC150-25UG 04055977209471

    Documentation

    Anti-β-Amyloid (1-42) Rabbit pAb MSDS

    Title

    Safety Data Sheet (SDS) 

    Anti-β-Amyloid (1-42) Rabbit pAb Certificates of Analysis

    TitleLot Number
    PC150

    References

    Przegląd literatury
    Savage, M.J., et al. 1998. J. Neurosci. 15, 1743.
    Borchelt, D.R., et al. 1997. Neuron 19, 939.
    Citron, M., et al. 1997. Nature Med. 3, 67.
    Hardy, J. 1997. Trends in Neurosci. 20, 154.
    Solomon, B., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 4109.
    Duff, K., et al. 1996. Nature 383, 710.
    Iwatsubo, T., et al. 1994. Neuron 13, 45.
    Suzuki, N., et al. 1994. Science 264, 133.
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision09-October-2007 RFH
    ApplicationDot Blot (0.1-0.5 µg/ml)
    ELISA (0.1-0.5 µg/ml)
    Radioimmunoassay (0.5 µg/ml)
    DescriptionRabbit polyclonal antibody adsorbed against Aβ1-40 and Aβ1-43, followed by immunoaffinity purification. Recognizes specifically β-amyloid peptide (1-42).
    BackgroundA number of mutations, identified in the gene encoding the β-amyloid precursor protein (βAPP), have been linked to early-onset Familial Alzheimer's Disease. Mutations in the genes encoding presenilin 1 and presenilin 2 have also been shown to alter the processing of βAPP, resulting in increased extracellular concentration of β-amyloid peptide Aβ1-42(43) relative to Aβ1-40. Biophysical and biochemical experiments suggest that Aβ1-42(43) may serve as a catalyst for the aggregation and deposition of Aβ leading to neurotoxic effects associated with senile plaque formation. Furthermore, antibodies recognizing Aβ1-42 revealed that the long form of the peptide is increased in presenilin and βAPP mutants while other studies have used Aβ specific antibodies to prevent the in vitro fibrillar aggregation of Aβ.
    HostRabbit
    Immunogen speciesHuman
    Immunogena synthetic peptide corresponding to amino acids from a C-terminal fragment of human β-amyloid peptide (1-42)
    IsotypeIgG
    Specieshuman
    FormLiquid
    FormulationIn phosphate buffer, pH 7.4.
    Concentration Label Please refer to vial label for lot-specific concentration
    PreservativeNone
    CommentsThis antibody is specific for β-amyloid peptide [1-42] and shows no reactivity to β-amyloid peptide [1-40] or β-amyloid peptide [1-43]. This antibody is recommended for use in the quantitative determination of β-amyloid peptide [1-42]. The sensitivity level for sandwich ELISA is 15-25 pg. Antibody should be titrated for optimal results in individual systems.
    Storage Avoid freeze/thaw
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
    Toxicity Standard Handling
    ReferencesSavage, M.J., et al. 1998. J. Neurosci. 15, 1743.
    Borchelt, D.R., et al. 1997. Neuron 19, 939.
    Citron, M., et al. 1997. Nature Med. 3, 67.
    Hardy, J. 1997. Trends in Neurosci. 20, 154.
    Solomon, B., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 4109.
    Duff, K., et al. 1996. Nature 383, 710.
    Iwatsubo, T., et al. 1994. Neuron 13, 45.
    Suzuki, N., et al. 1994. Science 264, 133.