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12-353 Acetyl-Histone H4 (Lys5, 8, 12, 16) Peptide

Acetyl-Histone H4 (Lys5, 8, 12, 16) Peptide primarily used in Histone Acetyltransferase Assays (HAT).

Acetyl-Histone H4 (Lys5, 8, 12, 16) Peptide MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Histone Acetyltransferase Assay (HAT) UniProt Number: P62805 Entrez Gene Number: NM_003538.3
12-353
100 µg  
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Replacement Information

Tabela kluczowych gatunków

Key ApplicationsEntrez Gene NumberModificationsUni Prot Number
HATNM_003538.3 Acetylation P62805
Description
Catalogue Number12-353
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAcetyl-Histone H4 (Lys5, 8, 12, 16) Peptide
References
Product Information
Presentationsterile deionized water
Quality LevelMQ100
Applications
ApplicationAcetyl-Histone H4 (Lys5, 8, 12, 16) Peptide primarily used in Histone Acetyltransferase Assays (HAT).
Key Applications
  • Histone Acetyltransferase Assay (HAT)
Biological Information
Entrez Gene Number
Entrez Gene SummaryHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
Gene Symbol
  • HIST1H4A
  • H4/J
  • HIST1H4F
  • HIST1H4L
  • H4FN
  • H4FA
  • H4FH
  • HIST1H4H
  • H4F2
  • H4FM
  • H4/A
  • H4FK
  • H4FG
  • HIST2H4
  • H4FB
  • H4/K
  • HIST1H4I
  • H4/N
  • HIST1H4B
  • H4FE
  • H4/M
  • H4/a
  • HIST1H4E
  • HIST4H4
  • HIST2H4A
  • H4FC
  • H4FI
  • H4/H
  • HIST1H4C
  • H4/G
  • HIST1H4K
  • H4FJ
  • H4FD
  • H4/I
  • H4/B
  • H4/D
  • H4/C
  • HIST1H4J
  • HIST1H4D
  • H4/E
Modifications
  • Acetylation
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P62805 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
SIZE: 103 amino acids; 11367 Da
SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
SUBCELLULAR LOCATION: Nucleus.
PTM: Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). & Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.
SIMILARITY: SwissProt: P62805 ## Belongs to the histone H4 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by Dot Blot or Peptide Inhibition Assay.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions2 years at -20°C
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
12-353 04053252674143

Documentation

Acetyl-Histone H4 (Lys5, 8, 12, 16) Peptide MSDS

Title

Safety Data Sheet (SDS) 

Acetyl-Histone H4 (Lys5, 8, 12, 16) Peptide Certificates of Analysis

TitleLot Number
Acetyl-Histone H4 (Lys5, 8, 12, 16) Peptide - 17073 17073
Acetyl-Histone H4 (Lys5, 8, 12, 16) Peptide - 20874 20874
Histone H4 (Tetra Ac Lys) Peptide (Ac Lys 5, 8, 12, 16) - 2435050 2435050
Histone H4 (Tetra Ac Lys) Peptide (Ac Lys 5, 8, 12, 16) - 2450014 2450014
Histone H4 (Tetra Ac Lys) Peptide (Ac Lys 5, 8, 12, 16) 2964805
Histone H4 (Tetra Ac Lys) Peptide (Ac Lys 5, 8, 12, 16) 2930433
Histone H4 (Tetra Ac Lys) Peptide (Ac Lys 5, 8, 12, 16) - 2091933 2091933
Histone H4 (Tetra Ac Lys) Peptide (Ac Lys 5, 8, 12, 16) - 2227361 2227361
Histone H4 (Tetra Ac Lys) Peptide (Ac Lys 5, 8, 12, 16) - 2293677 2293677
Histone H4 (Tetra Ac Lys) Peptide (Ac Lys 5, 8, 12, 16) -2505161 2505161
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Alternative Format

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