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566660 Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem

A cell-permeable Smoothened Agonist, SAG, CAS 364590-63-6, modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM).

Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: N-Methyl-Nʹ-(3-pyridinylbenzyl)-Nʹ-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, SAG1.3

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566660
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Replacement Information

Tabla espec. clave

CAS #Empirical Formula
364590-63-6C₂₈H₂₈ClN₃OS • 2HCl • 2H₂O

Precios y disponibilidad

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      566660-5MG
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      Disponibilidad a confirmar Disponibilidad a confirmar
      Ingrese cantidad 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente
          Contact Customer Service

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          Description
          OverviewA cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Smo internalization. Shown to induce Hedgehog pathway activation (EC50 = ∼ 3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations. A 10 mM (500 µg/86 µl) solution of Smoothened Agonist, SAG (Cat. No. 566661) in H2O is also available.
          Catalogue Number566660
          Brand Family Calbiochem®
          SynonymsN-Methyl-Nʹ-(3-pyridinylbenzyl)-Nʹ-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, SAG1.3
          References
          ReferencesWang, J., et al. 2010. Proc. Natl. Acad. Sci. USA. 107, 9323.
          Meloni, A.R., et al. 2006. Mol. Cell. Biol. 26, 7750.
          Chen, W., et al. 2004. Science 306, 2257.
          Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
          Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
          Product Information
          CAS number364590-63-6
          FormLight yellow solid
          Hill FormulaC₂₈H₂₈ClN₃OS • 2HCl • 2H₂O
          Chemical formulaC₂₈H₂₈ClN₃OS • 2HCl • 2H₂O
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Número de referencia GTIN
          566660-1MG 07790788051570
          566660-5MG 04055977191578

          Documentation

          Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem Certificados de análisis

          CargoNúmero de lote
          566660

          Referencias bibliográficas

          Visión general referencias
          Wang, J., et al. 2010. Proc. Natl. Acad. Sci. USA. 107, 9323.
          Meloni, A.R., et al. 2006. Mol. Cell. Biol. 26, 7750.
          Chen, W., et al. 2004. Science 306, 2257.
          Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
          Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.

          Citas

          Título
        • Wang, J., et al. 2010. Proc. Natl. Acad. Sci. USA. 107, 9323.
          		•
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-February-2012 RFH
          SynonymsN-Methyl-Nʹ-(3-pyridinylbenzyl)-Nʹ-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, SAG1.3
          DescriptionA cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Smo internalization. Shown to induce Hedgehog pathway activation (EC50 ∼3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations.
          FormLight yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number364590-63-6
          Chemical formulaC₂₈H₂₈ClN₃OS • 2HCl • 2H₂O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml) or H₂O (25 mg/ml)
          Storage Protect from light
          +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesWang, J., et al. 2010. Proc. Natl. Acad. Sci. USA. 107, 9323.
          Meloni, A.R., et al. 2006. Mol. Cell. Biol. 26, 7750.
          Chen, W., et al. 2004. Science 306, 2257.
          Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
          Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
          Citation
        • Wang, J., et al. 2010. Proc. Natl. Acad. Sci. USA. 107, 9323.
          		•