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239763 Cycloheximide - CAS 66-81-9 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
66-81-9C₁₅H₂₃NO₄

Pricing & Availability

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239763-1GM
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      Glass bottle 1 gm
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      239763-5GM
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          Glass bottle 5 gm
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          Description
          OverviewAn antifungal antibiotic that inhibits protein synthesis in eukaryotes but not prokaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and other cell types. A 100 mg/ml solution of Cycloheximide (Cat. No. 239765) in DMSO (sterile-filtered) is also available.
          Catalogue Number239763
          Brand Family Calbiochem®
          References
          ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
          Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175.
          Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
          Waring, P. 1990. J. Biol. Chem. 265, 14476.
          Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174.
          Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.
          Product Information
          CAS number66-81-9
          FormOff-white solid
          Hill FormulaC₁₅H₂₃NO₄
          Chemical formulaC₁₅H₂₃NO₄
          Structure formula ImageStructure formula Image
          Quality LevelMQ200
          Biological Information
          Primary TargethFKBP12
          Primary Target K<sub>i</sub>3.4 µM
          Purity≥90% by assay
          Safety Information according to GHS
          RTECSMA4375000
          Safety Information
          R PhraseR: 28-40-51/53-61

          Very toxic if swallowed.
          Limited evidence of a carcinogenic effect.
          Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
          May cause harm to the unborn child.
          S PhraseS: 45-53-61

          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Avoid exposure - obtain special instructions before use.
          Avoid release to the environment. Refer to special instructions/safety data sheet.
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
          Global Trade Item Number
          Catalogue Number GTIN
          239763-1GM 07790788048907
          239763-5GM 07790788048914