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101500 AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem

AEBSF, CAS 30827-99-7, is a specific irreversible inhibitor of chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. A nontoxic alternative to PMSF and DFP.

AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(2-Aminoethyl)benzenesulfonylfluoride, HCl

Primary Target: chymotrypsin
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101500
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Overview

Key Spec Table

CAS #Empirical Formula
30827-99-7C₈H₁₀FNO₂S · HCl

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101500-50MG
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      Description
      OverviewSpecific, irreversible inhibitor of serine proteases. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). A β-secretase inhibitor that inhibits β-amyloid peptide (Aβ) production and enhances amyloid precursor protein (sAPPUα) secretion in several cell lines at millimolar concentrations. Use at the same molar concentrations (0.1-1.0 mM) as PMSF for most applications. Also available as a 50 mM solution in H2O (Cat. No. 508436).
      Catalogue Number101500
      Brand Family Calbiochem®
      Synonyms4-(2-Aminoethyl)benzenesulfonylfluoride, HCl
      Application Data
      References
      ReferencesCitron, M., et al. 1996. Neuron 17, 171.
      Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
      Mintz, G.R. 1993. BioPharm. 6, 34.
      Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
      Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
      Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
      Baker, B.R., and Cory, M. 1971. J. Med. Chem. 14, 119.
      Product Information
      CAS number30827-99-7
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₈H₁₀FNO₂S · HCl
      Chemical formulaC₈H₁₀FNO₂S · HCl
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Targetchymotrypsin
      Purity>97% by HPLC
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 2 months at 4°C. Slight hydrolysis occurs at alkaline pH (8-9).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      101500-50MG 04055977226331