Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

681640 Wee1 Inhibitor - CAS 622855-37-2 - Calbiochem

The Wee1 Inhibitor, also referenced under CAS 622855-37-2, controls the biological activity of Wee1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(2-Chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor V

Primary Target: Wee1
View Products on Sigmaaldrich.com
681640
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
622855-37-2C₂₀H₁₁ClN₂O₃

Products

Catalogue NumberPackaging Qty/Pack
681640-1MG Plastic ampoule 1 mg
Description
OverviewA pyrrolocarbazole compound that acts as a potent, ATP-binding site-targeting inhibitor of Wee1 (IC50 = 11 nM) in an ATP-competitive manner and displays ~40-fold selectivity over the related checkpoint kinase Chk1 (IC50 = 440 nM).
Catalogue Number681640
Brand Family Calbiochem®
Synonyms4-(2-Chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor V
References
ReferencesPalmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.
Product Information
CAS number622855-37-2
ATP CompetitiveY
FormLight orange solid
Hill FormulaC₂₀H₁₁ClN₂O₃
Chemical formulaC₂₀H₁₁ClN₂O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetWee1
Primary Target IC<sub>50</sub>11 nM
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
681640-1MG 04055977260182

Documentation

Wee1 Inhibitor - CAS 622855-37-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Wee1 Inhibitor - CAS 622855-37-2 - Calbiochem Certificates of Analysis

TitleLot Number
681640

References

Reference overview
Palmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
Synonyms4-(2-Chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor V
DescriptionA pyrrolocarbazole compound that acts as a poten, ATP-binding site-targeting inhibitor of Wee1 (IC50 = 11 nM) in an ATP-competitive manner and displays ~40-fold selectivity over the related checkpoint kinase Chk1 (IC50 = 440 nM).
FormLight orange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number622855-37-2
Chemical formulaC₂₀H₁₁ClN₂O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesPalmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.