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676494 VEGF Inhibitor, Je-11 - Calbiochem

VEGF Inhibitor, Je-11 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (RTELNVGIDFNWEYPAS)₂K-NH₂, VEGFR Tyrosine Kinase Inhibitor XI, VEGFR2 Kinase Inhibitor XII

Primary Target: Binds to VEGF and blocks its interaction with VEGFR-2
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₈₈H₂₇₃N₄₉O₅₇
Description
Overview

This product has been discontinued.



A dimerized peptide derived from the third Ig-like domain of the human vascular endothelial growth factor receptor-2 (VEGFR-2 or KDR/Flk-1) comprising residues 247 - 261. Acts as an inhibitor of VEGF-stimulated autophosphorylation of VEGFR-2 and inhibits the proliferation and migration of cultured microvascular endothelial cells. Binds to VEGF and blocks its interaction with VEGFR-2 (IC50 = 500 nM on extracellular VEGFR-2 fragments; IC50 = 30 µM on HUVEC).
Catalogue Number676494
Brand Family Calbiochem®
Synonyms(RTELNVGIDFNWEYPAS)₂K-NH₂, VEGFR Tyrosine Kinase Inhibitor XI, VEGFR2 Kinase Inhibitor XII
References
ReferencesPiossek, C., et al. 1999. J. Biol. Chem. 274, 5612.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₈₈H₂₇₃N₄₉O₅₇
Chemical formulaC₁₈₈H₂₇₃N₄₉O₅₇
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetBinds to VEGF and blocks its interaction with VEGFR-2
Primary Target IC<sub>50</sub>500 nM on extracellular VEGFR-2 fragments; 30 µM on HUVEC
Purity≥90% by HPLC
Physicochemical Information
Cell permeableN
Peptide Sequence(H-Arg-Thr-Glu-Leu-Asn-Val-Gly-Ile-Asp-Phe-Asn-Trp-Glu-Tyr-Pro-Ala-Ser)₂-Lys-NH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
676494 0

Documentation

VEGF Inhibitor, Je-11 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

VEGF Inhibitor, Je-11 - Calbiochem Certificates of Analysis

TitleLot Number
676494

References

Reference overview
Piossek, C., et al. 1999. J. Biol. Chem. 274, 5612.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-September-2008 RFH
Synonyms(RTELNVGIDFNWEYPAS)₂K-NH₂, VEGFR Tyrosine Kinase Inhibitor XI, VEGFR2 Kinase Inhibitor XII
DescriptionA dimerized peptide derived from the third Ig-like domain of the human vascular endothelial growth factor receptor-2 (VEGFR-2 or KDR/FLK-1) comprising residues 247-261. Acts as an inhibitor of VEGF-stimulated autophosphorylation of VEGFR-2 (IC50 = 500 nM on extracellular VEGFR-2 fragments; IC50 = 30 µM on HUVEC).
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₈₈H₂₇₃N₄₉O₅₇
Peptide Sequence(H-Arg-Thr-Glu-Leu-Asn-Val-Gly-Ile-Asp-Phe-Asn-Trp-Glu-Tyr-Pro-Ala-Ser)₂-Lys-NH₂
Purity≥90% by HPLC
SolubilityDMSO (5 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesPiossek, C., et al. 1999. J. Biol. Chem. 274, 5612.